The Potential of β-Hydroxy-β-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity

Drugs & Aging
Andrea P RossiMauro Zamboni

Abstract

Sarcopenia is defined as an age-related loss of skeletal muscle mass and function and is recognized as a major clinical problem for older people. Essential amino acid supplementation, particularly β-hydroxy-β-methylbutyrate (HMB), a metabolite of leucine that is produced in skeletal muscle, has been evaluated in several studies as a nutritional approach to enhancing muscle protein synthesis in healthy or frail elderly subjects. Studies performed in in vitro conditions show that HMB may be effective in the treatment of muscle wasting, increasing myogenesis, reducing muscle apoptosis, and having a positive effect on muscle protein turnover; however, studies of the effects of HMB conducted in old animals have reported conflicting results. Clinical trials performed in older adults confirm that HMB can attenuate the progression of sarcopenia in elderly subjects. HMB supplementation results in an increase in skeletal muscle mass and strength in the elderly and its effect is even greater when combined with physical exercise. The role of HMB in sarcopenic obesity management is still under debate and a general lack of intervention studies in this population must be recognized. In conclusion, HMB appears to be effective for enhancing mus...Continue Reading

References

Apr 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S GuérinP Auberger
Mar 4, 2003·The Journal of Nutrition·Jane E KerstetterKarl L Insogna
Nov 16, 2005·International Journal of Sport Nutrition and Exercise Metabolism·Ken A van SomerenGlyn Howatson
May 13, 2008·The American Journal of Clinical Nutrition·Victor L Fulgoni
Oct 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·Helen L EleyMichael J Tisdale
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Jul 16, 2010·Journal of the American Medical Directors Association·John E MorleyUNKNOWN Society for Sarcopenia, Cachexia, and Wasting Disease
Jan 18, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F Gerlinger-RomeroM T Nunes
Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanlei HaoStephen E Alway
Nov 15, 2011·European Journal of Applied Physiology·Carlos Hermano da Justa PinheiroRui Curi
Apr 20, 2012·Journal of the International Society of Sports Nutrition·Jacob M WilsonJeong-Su Kim
Jun 19, 2012·Biochemical and Biophysical Research Communications·Zaira AversaPer-Olof Hasselgren
Mar 22, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E P DeutzRobert R Wolfe
Mar 23, 2013·The FEBS Journal·Stefano SchiaffinoMarco Sandri
Jul 24, 2013·Metabolism: Clinical and Experimental·Bong-Sup ParkJeong-Su Kim
Oct 22, 2013·Metabolism: Clinical and Experimental·Per-Olof Hasselgren
Nov 18, 2014·Journal of Nutrition and Metabolism·Chunzi LiangMichael B Zemel
Nov 19, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David W RussSean M Garvey
Jan 23, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E DeutzUNKNOWN NOURISH Study Group
Feb 13, 2016·Canadian Journal of Physiology and Pharmacology·Maha H SharawyNariman M Gameil

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Citations

Feb 7, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Mariëlle P K J Engelen, Nicolaas E P Deutz
Nov 27, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C H De FréS M Francque
Oct 16, 2019·Journal of Surgical Oncology·Casey J AllenBrian D Badgwell
Oct 25, 2020·Current Nutrition Reports·Khushboo GalaStephen A McClave
May 22, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern
Aug 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern

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