The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer.

European Journal of Nuclear Medicine and Molecular Imaging
M J WillhauckChristine Spitzweg

Abstract

We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I. In the current study, we studied the potential of the high-energy alpha-emitter (211)At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of (131)I due to rapid iodide efflux. We investigated uptake and therapeutic efficacy of (211)At in LNCaP cells stably expressing NIS under the control of the PSA promoter (NP-1) in vitro and in vivo. NP-1 cells concentrated (211)At in a perchlorate-sensitive manner, which allowed a dramatic therapeutic effect in vitro. After intraperitoneal injection of (211)At (1 MBq), NP-1 tumors accumulated approximately 16% ID/g (211)At (effective half-life 4.6 h), which resulted in a tumor-absorbed dose of 1,580+/-345 mGy/MBq and a significant tumor volume reduction of up to 82+/-19%, while control tumors continued their growth exponentially. A significant therapeutic effect of (211)At has been demonstrated in prostate cancer after PSA promoter-directed NIS gene transfer in vitro and in v...Continue Reading

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Citations

Jan 20, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kathrin KlutzChristine Spitzweg
May 19, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kerstin KnoopChristine Spitzweg
Nov 13, 2010·World Journal of Gastroenterology : WJG·Hong-Yan YinYi-Fan Zhang
Apr 1, 2010·Nuclear Medicine and Molecular Imaging·June-Key ChungKeon Wook Kang
Jun 4, 2011·Expert Opinion on Biological Therapy·Peggy Richard-FiardoBéatrice Cambien
May 10, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sarah UrnauerChristine Spitzweg
Apr 9, 2014·The Journal of Clinical Endocrinology and Metabolism·Garcilaso Riesco-EizaguirreAntonio De la Vieja
Nov 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Narges K TafreshiDavid L Morse
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathrin KlutzChristine Spitzweg
Nov 21, 2020·Translational Oncology·Fabio Castillo-RiveraThierry Pourcher
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kerstin KnoopChristine Spitzweg
Jul 3, 2021·The FEBS Journal·Iris KemlerDavid Dingli

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