The potential of azole antifungals against latent/persistent tuberculosis

FEMS Microbiology Letters
Zahoor AhmadG K Khuller

Abstract

The aim of the present study was to evaluate the chemotherapeutic potential of econazole against latent tuberculosis. The activity of econazole and clotrimazole was tested against the latent bacilli (Mycobacterium tuberculosis H(37)Rv) developed by nutrient starvation under in vitro conditions and by drugs under in vivo conditions. The latent bacteria developed under in vitro latent conditions were acid-fast negative, nonreplicating, resistant to conventional antitubercular drugs and showed low respiration rates. Econazole as well as clotrimazole were found to have strong antimycobacterial potential against latent Mycobacterium tuberculosis under in vitro conditions as seen by reductions in colony-forming units. Further, econazole prevented the formation of drug-induced latency and significantly reduced bacterial burden from lungs and spleens of latent tuberculosis-infected mice. We conclude that azole drugs bear significant therapeutic potential against latent tuberculosis.

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Citations

Mar 21, 2007·Biochemistry·Alexandra IoanoviciuPaul R Ortiz de Montellano
Oct 13, 2010·Nature Reviews. Microbiology·Gareth GriffithsGopal K Khuller
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pascal BelinMuriel Gondry
Jul 17, 2009·The Journal of Biological Chemistry·Larissa M PodustPaul R Ortiz de Montellano
Dec 20, 2007·The Journal of Biological Chemistry·Hugues OuelletPaul R Ortiz de Montellano
Nov 1, 2011·Antimicrobial Agents and Chemotherapy·Christopher R J AgnewR Leo Brady
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Sep 2, 2011·Future Medicinal Chemistry·Alexis NzilaKelly Chibale
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Aug 16, 2006·FEMS Microbiology Letters·Zahoor AhmadG K Khuller
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