The potential of cannabidiol in the COVID-19 pandemic.

British Journal of Pharmacology
Giuseppe EspositoGiovanni Sarnelli

Abstract

Identifying drugs effective in the new coronavirus disease 2019 (COVID-19) is crucial, pending a vaccine against SARS-CoV2. We suggest the hypothesis that cannabidiol (CBD), a non-psychotropic phytocannabinoid, has the potential to limit the severity and progression of the disease for several reasons:- (a) High-cannabidiol Cannabis sativa extracts are able to down-regulate the expression of the two key receptors for SARS-CoV2 in several models of human epithelia, (b) cannabidiol exerts a wide range of immunomodulatory and anti-inflammatory effects and it can mitigate the uncontrolled cytokine production responsible for acute lung injury, (c) being a PPARγ agonist, it can display a direct antiviral activity and (d) PPARγ agonists are regulators of fibroblast/myofibroblast activation and can inhibit the development of pulmonary fibrosis, thus ameliorating lung function in recovered patients. We hope our hypothesis, corroborated by preclinical evidence, will inspire further targeted studies to test cannabidiol as a support drug against the COVID-19 pandemic. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10...Continue Reading

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Citations

Oct 2, 2020·Journal of Medical Internet Research·Kamila JanmohamedNavin Kumar
Dec 10, 2020·Phytotherapy Research : PTR·Marcella PesceGiuseppe Esposito
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Jan 21, 2021·International Journal of Molecular Sciences·Anna StasiłowiczJudyta Cielecka-Piontek
Mar 9, 2021·Drug Metabolism Reviews·Ondine LucaciuDragoș Apostu
Mar 2, 2021·Frontiers in Immunology·Nicole PalandIgal Louria-Hayon
Mar 5, 2021·International Medical Case Reports Journal·Mark Mohan KaggwaScholastic Ashaba
Feb 23, 2021·Cannabis and Cannabinoid Research·Saoirse E O'SullivanSteven R Laviolette
Mar 7, 2021·International Journal of Molecular Sciences·Barbara MalinowskaEberhard Schlicker
Apr 6, 2021·Journal of Food Biochemistry·Morteza Ghasemnejad-Berenji
Apr 22, 2021·International Journal of Peptide Research and Therapeutics·Abbas JafariMorteza Ghasemnejad-Berenji
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jakub JakowieckiSławomir Filipek
May 11, 2021·Frontiers in Pharmacology·G KanimozhiN Rajendra Prasad
Jun 3, 2021·Journal of Personalized Medicine·Cristian ScheauAna Caruntu
Aug 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Apu ChowdhurySicen Wang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał GraczykTomasz Dzierżanowski
Sep 22, 2021·Journal of Cheminformatics·Rosa AghdamGolnaz Taheri

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