The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL

Therapeutics and Clinical Risk Management
Matthew H ForsbergChristian M Capitini

Abstract

Recent advancements in immunooncology have resulted in the generation of novel therapies such as chimeric antigen receptor (CAR) T cells, which have revolutionized the treatment of pediatric patients with relapsed or refractory B-cell acute lymphoblastic leukemia. The journey of tisagenlecleucel (formerly CTL019) from early preclinical success to the US Food and Drug Administration approval is summarized in this review. Strategies that are currently being investigated to improve the efficacy and safety profile of CAR T-cells are also explored, as well as the factors contributing to the present state of patient access to CAR T therapy.

Citations

Jul 11, 2019·CNS Oncology·Samia AsifShahzad Raza
Mar 28, 2019·Expert Opinion on Investigational Drugs·Marte Karen BrattåsØystein Bruserud
Nov 2, 2019·Clinics in Laboratory Medicine·Hugues Allard-Chamard
Mar 19, 2021·PloS One·Christine AmbrosePaul D Rennert

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Methods Mentioned

BETA
leukapheresis
lymphodepletion
xenografts

Clinical Trials Mentioned

NCT02746952
NCT02808442
NCT03241940
NCT03207178

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