The potential of coumatetralyl enhanced by cholecalciferol in the control of anticoagulant-resistant Norway rats (Rattus norvegicus)

Pest Management Science
Stefan EndepolsFranz-Rainer Matuschka

Abstract

We evaluated the potential of cholecalciferol as an enhancer of the first-generation anticoagulant coumatetralyl in the Westphalia anticoagulant-resistant strain of the Norway rat (Rattus norvegicus Berkenhout), characterised by the Tyr139Cys polymorphism on the VKOR enzyme. Because today only the most potent, but also most persistent anticoagulant rodenticides of the second generation remain available to control this strain, new rodenticide solutions are required. Feeding trials in the laboratory confirmed a significant level of efficacy, which was corroborated by field trials in the Münsterland resistance area. After frequency and level of resistance were assessed by blood clotting response tests, field trials were conducted with bait containing coumatetralyl at 375 mg kg(-1) and cholecalciferol at 50 mg kg(-1) or 100 mg kg(-1) . Control success was 94% when a large rat infestation comprising 42% resistant animals was treated. Another field trial applying the combination to a rat population that had survived a preceding treatment with bromadiolone resulted in a 99.5% control success according to the first census day, but with some increase in rat activity during subsequent census days. The combination of coumatetralyl and cho...Continue Reading

References

Jun 29, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M H Kohn, H J Pelz
Apr 23, 2003·Preventive Veterinary Medicine·S EndepolsK-L Ziebell
Apr 20, 2014·The Science of the Total Environment·Norberto Ruiz-SuárezOctavio P Luzardo
Aug 5, 2014·The Science of the Total Environment·Anke GeduhnJens Jacob
Dec 15, 2015·The Science of the Total Environment·Anke GeduhnJens Jacob

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Citations

Jan 10, 2017·Pest Management Science·Jordi FiguerolaJens Jacob
May 18, 2021·The Science of the Total Environment·Bernd WaltherJens Jacob

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