The potential of drug repositioning as a short-term strategy for the control and treatment of COVID-19 (SARS-CoV-2): a systematic review

Archives of Virology
William Gustavo LimaWaleska Stephanie da Cruz Nizer

Abstract

The novel human coronavirus (SARS-CoV-2), the causative agent of COVID-19, has quickly become a threat to the public health and economy worldwide. Despite the severity of some cases, there are no current pathogen-specific antivirals available to treat the disease. Therefore, many studies have focused on the evaluation of the anti-SARS-CoV-2 activity of clinically available drugs. Here, we conducted a systematic review to describe the drug repositioning strategy against SARS-CoV-2 and to discuss the clinical impact of this approach in the current pandemic context. The systematic review was performed on March 23, 2020, using PubMed/MEDLINE, Scopus, Cochrane Library, and Biblioteca Virtual de Saúde (BVS). The data were summarized in tables and critically analyzed. After the database search, 12 relevant studies were identified as eligible for the review. Among the drugs reported in these studies, 57 showed some evidence of antiviral activity. Antivirals, especially antiretrovirals, are the main class of therapeutic agents evaluated against COVID-19. Moreover, studies have reported the anti-SARS-CoV-2 activity of antitumor (16%; 9/57), antimalarial (7%, 4/57), and antibacterial (5%; 3/57) agents. Additionally, seven pharmacological ...Continue Reading

References

Mar 29, 2003·Drugs·Risto S Cvetkovic, Karen L Goa
Sep 8, 2004·Biochemical and Biophysical Research Communications·Els KeyaertsMarc Van Ranst
Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Aug 10, 2007·Nature·Curtis R Chong, David J Sullivan
Apr 9, 2008·Current Medicinal Chemistry·Y S BoriskinS J Polyak
Jun 10, 2011·Journal of Postgraduate Medicine·B M Padhy, Y K Gupta
Apr 29, 2014·Antiviral Research·Julie BlaisingEve-Isabelle Pécheur
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Dec 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·William Gustavo LimaAdriana Cristina Soares
Jul 26, 2019·Nature Reviews. Microbiology·Thomas HoenenHeinz Feldmann
Jan 24, 2020·JAMA : the Journal of the American Medical Association·Catharine I PaulesAnthony S Fauci
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
Feb 9, 2020·Nature Reviews. Rheumatology·Eva Schrezenmeier, Thomas Dörner
Feb 12, 2020·Travel Medicine and Infectious Disease·Alfonso J Rodríguez-MoralesPatricia Schlagenhauf
Mar 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pingzheng MoYongxi Zhang
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang

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Citations

Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga TarasovaVladimir Poroikov
Aug 20, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Haleh TalaieAli Firoozfar
Nov 11, 2020·Molecular Medicine·Betty DiamondYousef Al Abed
Nov 10, 2020·Current Opinion in HIV and AIDS·Rowena Johnston
Jan 2, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daniele GeneraliAngelo Pan
Jan 1, 2021·Journal of Structural Biology·Munazza Shahid, Syed Shahzad-Ul-Hussan
Aug 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ronald N KostoffAristidis Tsatsakis
Feb 3, 2021·Cardiovascular Drugs and Therapy·E F MagavernM Pirmohamed
Feb 18, 2021·Life Science Alliance·Mengran WangSusan Dina Ghiassian
Apr 20, 2021·Frontiers in Research Metrics and Analytics·Alan L PorterMengjia Wu
Dec 24, 2020·Expert Review of Anti-infective Therapy·Md Jamal Hossain, S M Abdur Rahman
Sep 3, 2021·Computational and Structural Biotechnology Journal·Lucía Prieto SantamaríaAlejandro Rodríguez-González
Oct 9, 2021·Briefings in Bioinformatics·Qiaoming LiuGuohua Wang
Dec 29, 2021·Briefings in Bioinformatics·Angela SerraDario Greco
Jan 26, 2022·ACS Synthetic Biology·Anooshay KhanUrartu Ozgur Safak Seker

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Clinical Trials Mentioned

NCT04292899
NCT04273529
NCT04308317
NCT04318015
NCT04316377
NCT04260594
NCT04286503
NCT04303299
NCT04311177
NCT04275414

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