The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Gilbert O FruhwirthErik H J G Aarntzen

Abstract

This review aims to emphasize the potential of in vivo imaging to optimize current and upcoming anti-cancer immunotherapies: spanning from preclinical to clinical applications. Immunotherapies are an emerging class of treatments for a variety of diseases. The agents include molecular and cellular therapeutics, which aim to treat the disease through re-education of the host immune system, often via complex mechanisms of action. In vivo imaging has the potential to contribute in several different ways: (1) as a drug development tool to improve our understanding of their complex mechanisms of action, (2) as a tool to predict efficacy, for example, to stratify patients into probable responders and likely non-responders, and (3) as a non-invasive treatment response biomarker to guide efficient immunotherapy use and to recognize early signs of potential loss of efficacy or resistance in patients. Areas where in vivo imaging is already successfully implemented in onco-immunology research will be discussed and domains where its use offers great potential will be highlighted. The focus of this article is on anti-cancer immunotherapy as it currently is the most advanced immunotherapy area. However, the described concepts can also be para...Continue Reading

References

Jan 5, 2002·Neoplasia : an International Journal for Oncology Research·V PonomarevJ G Tjuvajev
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Nov 1, 2005·Nature Biotechnology·I Jolanda M de VriesCarl G Figdor
Jun 2, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TherasseM Buyse
Apr 1, 2008·Nature Medicine·Martin S JudenhoferBernd J Pichler
Apr 4, 2008·Nature·Ralph Weissleder, Mikael J Pittet
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D J SargentL K Shankar
Dec 20, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan BogaertsUNKNOWN RECIST Working Party
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jan 28, 2009·Nature Reviews. Immunology·Philippe Bousso
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jedd D WolchokF Stephen Hodi
Feb 13, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Antoni RibasJohannes Czernin
Feb 25, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard A MorganSteven A Rosenberg
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Jul 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Joost LesterhuisCarl G Figdor
Sep 29, 2011·Nature Reviews. Clinical Oncology·Moritz F KircherJan Grimm
Nov 4, 2011·The New England Journal of Medicine·Antonio Di StasiMalcolm K Brenner
Feb 23, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sebastian TemmeUlrich Flögel
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jan 16, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter BraderRonald G Blasberg
Feb 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erik H J G AarntzenI Jolanda M de Vries
Feb 13, 2013·The Lancet Oncology·Richard A DiazJane Adam
Apr 13, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Behdad AfzaliGiovanna Lombardi
Jul 31, 2013·Immunity·Daniel S Chen, Ira Mellman
Sep 10, 2013·Nature Reviews. Immunology·Eric T Ahrens, Jeff W M Bulte
Oct 31, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lanell M PetersonHannah M Linden
Dec 7, 2013·Endocrine Reviews·Carla PortulanoNancy Carrasco
Dec 21, 2013·Science·Jennifer Couzin-Frankel
Jan 24, 2014·Nature Materials·Ralph WeisslederMikael J Pittet
Feb 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sumithra J MandrekarDaniel J Sargent
Apr 5, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mark A CastanaresMartin G Pomper
Jul 24, 2014·The New England Journal of Medicine·Richard S Hotchkiss, Lyle L Moldawer
Aug 6, 2014·Nature Biotechnology·Anna V NaumovaJoseph A Frank
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N KochenderferSteven A Rosenberg
Oct 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana C Parente-PereiraJohn Maher
Jan 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hans F WehrlBernd J Pichler
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk SchadendorfJedd D Wolchok
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
Apr 22, 2015·The New England Journal of Medicine·Michael A PostowF Stephen Hodi
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mohammad RashidianHidde L Ploegh
May 16, 2015·Cancer Research·Sandra HeskampOtto C Boerman

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Citations

Nov 9, 2019·Journal of Clinical Medicine·Maria Felicia FiordelisiMarco Salvatore
Nov 7, 2019·EJNMMI Radiopharmacy and Chemistry·Peter WierstraSandra Heskamp
Feb 6, 2019·Nature Reviews. Clinical Oncology·Mirjam GerwingMoritz Wildgruber
Jul 10, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Angelo Castello, Egesta Lopci
Mar 3, 2020·Frontiers in Medicine·Justine PerrinJacques Barbet
Oct 11, 2019·Contrast Media & Molecular Imaging·M F FiordelisiA Greco
May 5, 2021·Cancer Immunology Research·Zebin Xiao, Ellen Puré
Apr 4, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Candice Ashmore-HarrisGilbert O Fruhwirth
Jul 3, 2021·Vaccines·Matthieu Van TilbeurghCaroline Manet
Jul 25, 2021·International Journal of Molecular Sciences·Inez WensNathalie Cools
Nov 1, 2021·Drug Discovery Today·Jelter Van HoeckKoen Raemdonck

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Methods Mentioned

BETA
imaging techniques

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