The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk.

Neurotoxicology
Kevin K KumarAaron B Bowman

Abstract

An important goal of neurotoxicological research is to provide relevant and accurate risk assessment of environmental and pharmacological agents for populations and individuals. Owing to the challenges of human subject research and the real possibility of species specific toxicological responses, neuronal lineages derived from human embryonic stem cells (hESCs) and human neuronal precursors have been offered as a potential solution for validation of neurotoxicological data from model organism systems in humans. More recently, with the advent of induced pluripotent stem cell (iPSC) technology, there is now the possibility of personalized toxicological risk assessment, the ability to predict individual susceptibility to specific environmental agents, by this approach. This critical advance is widely expected to facilitate analysis of cellular physiological pathways in the context of human neurons and the underlying genetic factors that lead to disease. Thus this technology opens the opportunity, for the first time, to characterize the physiological, toxicological, pharmacological and molecular properties of living human neurons with identical genetic determinants as human patients. Furthermore, armed with a complete clinical hist...Continue Reading

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Citations

Oct 16, 2013·Neurotoxicology·Remco H S Westerink
Jul 6, 2013·Journal of Bioscience and Bioengineering·Hideki Mori, Masayuki Hara
Mar 9, 2013·Toxicology Letters·Clay W ScottYvonne P Dragan
Sep 27, 2012·Neurotoxicology and Teratology·Jared J SchwartzerRobert F Berman
Oct 29, 2014·Scientific Reports·Kevin K KumarAaron B Bowman
Feb 26, 2015·Journal of Tissue Engineering and Regenerative Medicine·Imogen SmithBenjamin J Whalley
May 28, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christina M PowersPatricia A Gillespie
Nov 5, 2014·Stem Cells Translational Medicine·Xianmin ZengMahendra Rao
Feb 13, 2020·The Journal of Biological Chemistry·Kyle J HorningAaron B Bowman
Sep 21, 2018·Frontiers in Neuroscience·Alastair I GraingerEric J Hill
Oct 17, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marta Barenys, Ellen Fritsche
Oct 1, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·M Diana NeelyAaron B Bowman
Feb 16, 2021·Expert Opinion on Drug Metabolism & Toxicology·Emma E J Kasteel, Remco H S Westerink
Feb 17, 2021·Biomedical Materials·Uzair AhmedAnwarul Hasan

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