The potential of microvessel density in prediction of infarct growth: a two-month experimental study in vessel size imaging

Cerebrovascular Diseases
Chao XuJochen B Fiebach

Abstract

Vessel size imaging is a novel technique to evaluate pathological changes of the microvessel density quantity Q and the mean vessel size index (VSI). As a follow-up study, we assessed these parameters for microscopic description of ischemic penumbra and their potentials in predicting lesion growth. Seventy-five patients with a perfusion-diffusion mismatch were examined within 24 h from symptom onset. We defined three regions of interest: the initial infarct (INF), the ischemic penumbra (IPE), and the healthy region (HEA) symmetric to the IPE. For 23 patients with a 6th-day follow-up, IPE regions were divided into areas of infarct growth and areas of oligemia. The median values of Q and VSI were: for INF 0.29 s(-1/3) and 15.8 μm, for IPE 0.33 s(-1/3) and 20.6 μm and for HEA 0.36 s(-1/3) and 17.4 μm. The Q in the IPE was significantly smaller than in HEA, and VSI was significantly larger. The Q with a threshold of 0.32 s(-1/3) predicted the final infarction with a sensitivity of 69% and a specificity of 64%. The reduced Q and increased VSI in the IPE confirmed our previous pilot results. Although Q showed a trend to identify the severity of ischemia in an overall voxel population, its potential in predicting infarct growth needs ...Continue Reading

References

Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L OstergaardB R Rosen
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·D G DarbyS M Davis
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J H Jensen, R Chandra
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I TroprèsM Décorps
Mar 9, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I TroprèsC Rémy
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·V G KiselevJ Hennig
Mar 26, 2005·Stroke; a Journal of Cerebral Circulation·Jan SobeskyWolf-Dieter Heiss
Dec 3, 2005·Stroke; a Journal of Cerebral Circulation·C S RiversM S Dennis
Feb 3, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kim MouridsenLeif Ostergaard
May 15, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chien-Yuan LinTeng-Nan Lin
Sep 4, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Asamoah BosomtwiMichael Chopp
Jun 6, 2009·Stroke; a Journal of Cerebral Circulation·Stephen M Davis, Geoffrey A Donnan
Oct 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Yuan-Yu HsuHo-Ling Liu
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Olivier Zaro-WeberJan Sobesky
Apr 15, 2010·Cerebrovascular Diseases·Bruce C V CampbellUNKNOWN EPITHET Investigators
Apr 24, 2010·Stroke; a Journal of Cerebral Circulation·Fernando CalamanteAlan Connelly
Jul 1, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Umeo ItoKiyomitsu Oyanagi
Sep 23, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kohsuke KudoAkira Ogawa
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Pedro Ramos-CabrerJosé Castillo
Apr 7, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chao XuJochen B Fiebach

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Citations

Mar 22, 2013·PloS One·Nicolas Adrien PannetierEmmanuel Luc Barbier
Aug 30, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Irène TroprèsEmmanuel L Barbier
Jun 7, 2013·Contrast Media & Molecular Imaging·Philipp Boehm-SturmMathias Hoehn
Oct 30, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nicolas A PannetierNorbert Schuff
Sep 25, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marco FoddisCeleste Sassi
Apr 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna KufnerAlexander H Nave
Dec 24, 2021·Clinical Neuroradiology·Asmaa FodaIvana Galinovic

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