The potential of PDE4 inhibitors in respiratory disease

Current Drug Targets. Inflammation and Allergy
Domenico Spina

Abstract

Glucocorticosteroids remain the gold standard therapy for the prophylactic treatment of asthma. Concerns regarding its long-term use particularly in young children has provided an impetus for discovering novel anti-inflammatory molecules with high tolerability and clinical efficacy. Whilst for chronic obstructive pulmonary disease (COPD), there exist no pharmacological treatment for the prevention of decline in lung function. Targeting phosphodiesterase (PDE)4 is one example of this approach and inhibitors of this enzyme are the most advanced drug class in the respiratory pipeline. A number of potent PDE4 inhibitors have undergone clinical trials with moderate success. Tolerability and clinical efficacy issues have dampened enthusiasm in this area. However, with the prospect of newer potent and side effect free inhibitors on the horizon give this area guarded optimism. This review will summarise the most recent information concerning the effectiveness of PDE4 inhibitors as novel anti-inflammatory agents for the treatment of respiratory diseases.

Citations

Jun 1, 2005·Pharmacology & Therapeutics·María Jesús SanzEsteban J Morcillo
Aug 15, 2012·Journal of Medicinal Chemistry·Neil J PressAlexandre Trifilieff
Jul 1, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sarah GerloRon Kooijman
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Desuo Wang, Xiangli Cui
Aug 19, 2006·Expert Opinion on Investigational Drugs·Victoria Boswell-Smith, Clive P Page
Jul 29, 2008·British Journal of Pharmacology·D Spina
Jul 1, 2012·Molecular Informatics·Gülşah ÇifciE Demet Akten
Nov 2, 2005·Cellular Signalling·Shireen-A Davies
Nov 1, 2005·Drug Discovery Today·Miles D HouslayKam Y J Zhang
Apr 14, 2012·Current Opinion in Pharmacology·Clive P Page, Domenico Spina
Jun 15, 2006·Nature Reviews. Drug Discovery·Luke A J O'Neill
Apr 4, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Vera P Krymskaya
Jan 28, 2005·The Biochemical Journal·Jonathan P DayShireen-A Davies
Nov 1, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aaron ErdelySidney M Morris
Oct 29, 2005·The Journal of Pharmacology and Experimental Therapeutics·S VidelaJ-R Malagelada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.