The potential of predictive analytics to provide clinical decision support in depression treatment planning

Current Opinion in Psychiatry
R C Kessler

Abstract

To review progress developing clinical decision support tools for personalized treatment of major depressive disorder (MDD). Over the years, a variety of individual indicators ranging from biomarkers to clinical observations and self-report scales have been used to predict various aspects of differential MDD treatment response. Most of this work focused on predicting remission either with antidepressant medications versus psychotherapy, some antidepressant medications versus others, some psychotherapies versus others, and combination therapies versus monotherapies. However, to date, none of the individual predictors in these studies has been strong enough to guide optimal treatment selection for most patients. Interest consequently turned to decision support tools made up of multiple predictors, but the development of such tools has been hampered by small study sample sizes. Design recommendations are made here for future studies to address this problem. Recommendations include using large prospective observational studies followed by pragmatic trials rather than smaller, expensive controlled treatment trials for preliminary development of decision support tools; basing these tools on comprehensive batteries of inexpensive self...Continue Reading

References

Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Charles B NemeroffMartin B Keller
Sep 22, 2005·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Patricia LinSusan C Hedrick
Nov 16, 2006·BMC Medical Informatics and Decision Making·Pablo PerelIan Roberts
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Rudolf UherPeter McGuffin
Feb 25, 2011·The Journal of Nervous and Mental Disease·Glen I SpielmansAshley N Usitalo
Jul 28, 2011·BMC Medicine·Evelyn BrometRonald C Kessler
Sep 3, 2011·Journal of Affective Disorders·Baumeister Harald, Parker Gordon
Oct 5, 2011·BMJ : British Medical Journal·Johannes A N DorresteijnNancy R Cook
Oct 20, 2011·International Journal of Geriatric Psychiatry·Monique A PimontelJoel R Sneed
Mar 1, 2012·The Psychiatric Clinics of North America·Ronald C Kessler
Mar 21, 2012·Journal of Consulting and Clinical Psychology·Kate L HarknessSidney H Kennedy
Jul 20, 2012·European Journal of Preventive Cardiology·David Prieto-Merino, Stuart J Pocock
Nov 24, 2012·The British Journal of Psychiatry : the Journal of Mental Science·J Elisabeth WellsRonald C Kessler
Dec 6, 2012·BMC Medicine·Hanna M van LooRobert A Schoevers
Feb 5, 2013·The American Journal of Psychiatry·UNKNOWN GENDEP InvestigatorsUNKNOWN STAR*D Investigators
May 1, 2013·Journal of the American Statistical Association·Yingqi ZhaoMichael R Kosorok
May 9, 2013·Journal of Psychiatric Practice·Chad D Rethorst, Madhukar H Trivedi
Jun 6, 2013·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Pim CuijpersCharles F Reynolds
Jun 14, 2013·JAMA Psychiatry·Callie L McGrathHelen S Mayberg
Jan 11, 2014·Annual Review of Psychology·W Edward Craighead, Boadie W Dunlop
Jun 27, 2014·American Journal of Epidemiology·Gordon C S SmithIan R White
Aug 5, 2014·Families, Systems & Health : the Journal of Collaborative Family Healthcare·Thomas J WaltzLisa V Rubenstein
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Gerhard AnderssonErik Hedman
Jan 2, 2015·Journal of Affective Disorders·Karolien E M Biesheuvel-LeliefeldFilip Smit
Apr 10, 2015·International Journal of Molecular Sciences·Kenji Hashimoto
Jul 15, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R StrawbridgeA J Cleare
Dec 9, 2015·The Australian and New Zealand Journal of Psychiatry·Gin S MalhiAjeet B Singh
Jan 27, 2016·Epidemiology and Psychiatric Sciences·R C KesslerA M Zaslavsky
Feb 9, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·A JobstF Padberg
Feb 13, 2016·The American Journal of Psychiatry·Jeffrey R VittenglPim Cuijpers
Feb 18, 2016·Occupational and Environmental Medicine·David Daniel EbertDirk Lehr
Apr 4, 2016·Journal of Psychiatric Research·Madhukar H TrivediMyrna M Weissman

❮ Previous
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Citations

Nov 30, 2019·Psychological Medicine·Johan OrmelSteven D Hollon
May 21, 2020·JAMA Psychiatry·Meredith G HarrisUNKNOWN WHO World Mental Health Survey Collaborators
Sep 16, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Mario MajHans-Ulrich Wittchen
Sep 24, 2020·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Suzanne C van BronswijkMarcus J H Huibers
Jan 8, 2019·International Journal of Methods in Psychiatric Research·Pim CuijpersRonald C Kessler
Mar 2, 2018·Annual Review of Clinical Psychology·Zachary D Cohen, Robert J DeRubeis
Feb 8, 2019·Bipolar Disorders·Thomas T KimAndrew A Nierenberg
Jan 13, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Mario MajJoseph Ventura
Feb 18, 2021·JAMA Psychiatry·Alex Luedtke, Ronald C Kessler
Feb 7, 2021·Acta Psychiatrica Scandinavica·Joshua E J BuckmanStephen Pilling
Apr 30, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Christine SigristJulian Koenig
Jun 1, 2021·Journal of Psychiatric Research·David P HerzogKlaus Lieb
May 30, 2021·Behaviour Research and Therapy·Shannon Wiltsey StirmanPaula P Schnurr
Mar 3, 2019·Behavior Therapy·Steven D HollonPaul W Andrews
Jan 6, 2022·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jan EngelmannMarianne B Műller

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