PMID: 8962643Mar 1, 1996Paper

The potential of the zona pellucida as a target for immunocontraception

American Journal of Reproductive Immunology : AJRI
R J AitkenM van Duin

Abstract

To investigate the contraceptive potential of the zona pellucida. Generation of antibodies against native and recombinant zona glycoproteins which have then been assessed for their capacity to disrupt sperm-zona interaction in vivo and in vitro. The animal model selected for these studies was the common marmoset and the end points examined were antibody titre, ovarian cyclicity and fertility. The fact that antibodies against the major zona glycoprotein, ZP3, block both the primary and secondary phases of sperm-zona interaction suggests that this molecule might have potential for contraceptive vaccine development. Active immunization of marmoset monkeys with native porcine ZP3 or recombinant human ZP3 produced long term infertility but also precipitated a premature decline in the primordial follicle population. Future studies will have to determine whether a safe, effective vaccine can be engineered by coupling unique B-cell epitopes from ZP3 to foreign T-cell antigens.

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Citations

Oct 19, 2002·Journal of Reproductive Immunology·R John Aitken
Jan 9, 1999·Journal of Reproductive Immunology·L E KerrR J Aitken
Mar 9, 2000·Journal of Reproductive Immunology·M R Barber, R A Fayrer-Hosken
Sep 16, 2000·Animal Reproduction Science·L A MillerG J Killian
Jun 15, 2005·ILAR Journal·Michael K Schunk, G Eileen Macallum
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Lisa A HarrenstienJay F Kirkpatrick
Jul 26, 2003·Expert Opinion on Biological Therapy·Eileen A McLaughlinR John Aitken
Sep 13, 2002·Expert Opinion on Investigational Drugs·Peter J Delves
Jan 20, 2016·American Journal of Reproductive Immunology : AJRI·Feng XueChen Xu
Sep 1, 2012·American Journal of Reproductive Immunology : AJRI·Xiaolin MaFuchun Zhang
Jun 21, 2014·Reproduction in Domestic Animals = Zuchthygiene·C MaenhoudtA Fontbonne
Jun 8, 2006·Theriogenology·Michelle Kutzler, Anna Wood
Feb 28, 2003·Biology of Reproduction·Ruo-Lan XiangJing-Pian Peng
Nov 26, 1999·Biology of Reproduction·S M SkinnerB S Dunbar
Aug 15, 2002·British Medical Bulletin·Pascal Mettens, Philippe Monteyne
Mar 13, 2003·Immunology and Cell Biology·Andréa MagiafoglouStephen W McKechnie
Sep 23, 2003·Gynécologie, obstétrique & fertilité·L Abdennebi-Najar

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