The potential of translational bioinformatics approaches for pharmacology research

British Journal of Clinical Pharmacology
Lang Li

Abstract

The field of bioinformatics has allowed the interpretation of massive amounts of biological data, ushering in the era of 'omics' to biomedical research. Its potential impact on pharmacology research is enormous and it has shown some emerging successes. A full realization of this potential, however, requires standardized data annotation for large health record databases and molecular data resources. Improved standardization will further stimulate the development of system pharmacology models, using translational bioinformatics methods. This new translational bioinformatics paradigm is highly complementary to current pharmacological research fields, such as personalized medicine, pharmacoepidemiology and drug discovery. In this review, I illustrate the application of transformational bioinformatics to research in numerous pharmacology subdisciplines.

References

Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M R Macleod
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzJames N Ingle
May 9, 2008·Molecular Systems Biology·Xuebing WuShao Li
Mar 6, 2009·Journal of the American Medical Informatics Association : JAMIA·Xiaoyan WangCarol Friedman
Apr 7, 2010·American Journal of Human Genetics·Marylyn D RitchieDan M Roden
Sep 18, 2010·Nature Reviews. Genetics·Matthew MeyersonGad Getz
May 27, 2011·Clinical Pharmacology and Therapeutics·Y PouliotA J Butte
Jun 16, 2011·Journal of the American Medical Informatics Association : JAMIA·Hua XuJoshua C Denny
Jun 17, 2011·Journal of the American Medical Informatics Association : JAMIA·Nicholas P TatonettiRuss B Altman
Aug 9, 2011·Journal of Biomedical Informatics·Adrian BentonJohn H Holmes
Oct 22, 2011·Bioinformatics·Assaf GottliebRoded Sharan
Nov 15, 2011·Journal of the American Medical Informatics Association : JAMIA·Mark A MusenUNKNOWN NCBO team
Feb 4, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yael SilberbergRoded Sharan
May 3, 2012·Clinical Pharmacology and Therapeutics·R HarpazC Friedman
May 3, 2012·Clinical Pharmacology and Therapeutics·R B Altman
May 23, 2012·Clinical Pharmacology and Therapeutics·P E ZhichkinD R Abernethy
Dec 14, 2012·Nature·Jérémy BesnardAndrew L Hopkins
Dec 18, 2012·Clinical Pharmacology and Therapeutics·R B Altman
Jan 17, 2013·Pharmacoepidemiology and Drug Safety·Jun J MaoJohn H Holmes
Feb 5, 2013·BMC Bioinformatics·Heng-Yi WuLang Li
Mar 8, 2013·Journal of the American Medical Informatics Association : JAMIA·Ryen W WhiteEric Horvitz
Jun 8, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Omri GottesmanUNKNOWN eMERGE Network
Jul 31, 2013·Nature Reviews. Genetics·Ehud ShapiroSten Linnarsson
Oct 30, 2013·Nature Genetics
Jan 10, 2014·Molecular BioSystems·Xiaodong PengSamy O Meroueh
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Huiying LiXiaolin Tong
Mar 1, 2014·Clinical Pharmacology and Therapeutics·A Gottlieb, R B Altman
Jul 22, 2014·Nature·Bing ZhangUNKNOWN NCI CPTAC
Jul 25, 2014·Clinical Pharmacology and Therapeutics·S Sarntivijai, D R Abernethy
Aug 6, 2014·Journal of Biomedical Semantics·Yongqun HeBarry Smith

❮ Previous
Next ❯

Citations

Sep 18, 2015·CPT: Pharmacometrics & Systems Pharmacology·L Li, P H van der Graaf
Sep 22, 2015·British Journal of Clinical Pharmacology·Michael Rieder, Albert Ferro
Dec 19, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fabian HeldDanijela Gnjidic
Jul 1, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Caroline Birer-WilliamsRichard D Boyce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Anatomy & Physiology : Current Research
Nancy Lan Guo
Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]
Brian Johnson
Clinical Pharmacology and Therapeutics
L J Lesko
© 2022 Meta ULC. All rights reserved