The potential protective role of caveolin-1 in intestinal inflammation in TNBS-induced murine colitis

PloS One
Carolyn R WeissZhikang Peng

Abstract

Caveolin-1 (Cav-1) is a multifunctional scaffolding protein serving as a platform for the cell's signal-transduction and playing an important role in inflammation. However, its role in inflammatory bowel disease is not clear. A recent study showed that Cav-1 is increased and mediates angiogenesis in dextran sodium sulphate-induced colitis, which are contradictory to our pilot findings in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. In the present study, we further clarified the role of Cav-1 in TNBS-induced colitis. In BALB/c mice, acute colitis was induced by intra-rectal administration of one dose TNBS, while chronic colitis was induced by administration of TNBS once a week for 7 weeks. To assess the effects of complete loss of Cav-1, Cav-1 knockout (Cav-1-/-) and control wild-type C57 mice received one TNBS administration. Body weight and clinical scores were monitored. Colon Cav-1 and pro-inflammatory cytokine levels were quantified through ELISAs. Inflammation was evaluated through histological analysis. Colon Cav-1 levels were significantly decreased in TNBS-induced colitis mice when compared to normal mice and also inversely correlated with colon inflammation scores and proinflammatory cytokine levels (IL...Continue Reading

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Citations

Feb 4, 2016·International Journal of Inflammation·Canan AlkimIlker Sen
Oct 5, 2019·Clinical and Translational Gastroenterology·Mona Dixon GundersenRuth Hracky Paulssen
Sep 25, 2018·Journal of Immunology Research·Elena CodriciMihail E Hinescu
Jul 1, 2019·Pediatric Surgery International·Hiroki NakamuraPrem Puri
May 29, 2020·Communications Biology·Seong-Hwan ParkYuseok Moon

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Methods Mentioned

BETA
enzyme linked immunosorbent assays
protein assay
ELISA
Assay

Software Mentioned

Image Pro Plus
GraphPad Prism

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