The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations

Clinical Biochemistry
Peter A KavsakAndrew Worster

Abstract

Elevated and non-changing high-sensitivity cardiac troponin (hs-cTn) concentrations may suggest a process other than acute injury, possibly due to chronic condition(s) causing the elevation, an analytical error/interference or the formation of macrocomplexes. Heart-type fatty acid binding protein (H-FABP) might be useful in this setting to identify the etiology of abnormally high and non-changing cTn concentrations which could aid clinical decision making in the hospital setting. We analytically validated the H-FABP assay (Randox) on the Abbott ARICHTECTc8000 platform, testing imprecision, linearity, stability, and matrix comparison. Over the 2-month analytical validation; EDTA plasma samples from patients with a hospital visit with persistently elevated and stable cTnI concentrations (Abbott hs-cTnI≥52 ng/L or 2x99th percentile upper limit of normal (ULN = 26 ng/L) with change between results <20%) were collected and frozen (-20 °C). These samples were tested with the H-FABP assay, polyethylene glycol (PEG) precipitation, with the lowest estimated glomerular filtration rate (eGRF) during the hospital visit also obtained from these patients. The H-FABP assay was linear, with concentrations stable after 4 freeze/thaw cycles, up ...Continue Reading

Citations

Nov 21, 2018·Critical Reviews in Clinical Laboratory Sciences·Magnus Nakrem LyngbakkenTorbjørn Omland
Feb 8, 2020·Clinical Chemistry·Leo LamCampbell Kyle
Oct 20, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael A VeraJoe M El-Khoury

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