The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis

Biological Psychiatry
Tara L TeppenSubhash C Pandey

Abstract

The antianxiety effects of ethanol appear to be a crucial factor in promoting alcohol intake. Regulation of gene expression by microRNA (miRNA) is an important epigenetic mechanism that affects neuronal pathways and behaviors. We investigated the role of miRNAs underlying the mechanisms of ethanol-induced anxiolysis. Acute ethanol-induced anxiolysis was measured in adult rats, and amygdaloid tissues were used for miRNA profiling by microarray analysis. The expression of miR-494 and its target genes in the amygdala was measured using real-time quantitative polymerase chain reaction. The direct role of miR-494 in the anxiety phenotype was also investigated via infusion of a miR-494 antagomir into the central nucleus of amygdala. Microarray profiling of miRNAs in the amygdala showed significant alteration of several miRNA expression levels by acute ethanol exposure. Expression of miR-494 was significantly decreased, whereas expression of the binding protein of cyclic adenosine monophosphate response element binding protein (CBP), p300, and Cbp/p300-interacting transactivator 2 (Cited2) was increased in the amygdala during ethanol-induced anxiolysis. Inhibition of miR-494 in the central nucleus of amygdala, through infusion of a sp...Continue Reading

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Citations

Apr 11, 2019·Alcoholism, Clinical and Experimental Research·Russell S DulmanSubhash C Pandey
Jul 25, 2019·Alcoholism, Clinical and Experimental Research·Fulton T CrewsRyan P Vetreno
Sep 13, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Haiping ZhaoYumin Luo
Sep 21, 2018·Frontiers in Cellular and Infection Microbiology·Qing ZhaoBo Wang
Jul 12, 2018·Scientific Reports·Huaibo ZhangSubhash C Pandey
Apr 27, 2017·Frontiers in Molecular Neuroscience·Alfredo GhezziNigel S Atkinson
Mar 23, 2021·Current Pathobiology Reports·Russell S DulmanSubhash C Pandey

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