The potential role of carbon dioxide in the neuroimmunoendocrine changes following cerebral ischemia

Life Sciences
Mohammadali M ShojaKhalil Ansarin

Abstract

Carbon dioxide (CO(2)) interacts in complex ways with the brain and the endocrine and immune systems. Arterial CO(2) may be elevated or decreased following cerebral ischemia-reperfusion injury or stroke. The aim of the present review is to delineate potential changes in the neuroimmunoendocrine system following cerebral ischemia-reperfusion injury and to provide evidence for the modulatory role of carbon dioxide in this setting. It appears that lesions of the right and left cerebral hemispheres are associated with different patterns of immune activation and cytokine release. Changes in arterial CO(2) can profoundly alter the neuroimmunoendocrine system, especially the hypothalamic-pituitary-adrenal (HPA) axis and the production of pro-inflammatory cytokines. Hypercapnia activates the HPA axis, exerts antiinflammatory and antioxidant effects, and can alter the secretion and function of various brain neurotransmitters. There is conflicting evidence surrounding arterial CO(2): its effects on the ischemic brain may be either beneficial or deleterious. Mild hypercapnia may exert some neuroprotection following cerebral ischemia, but severe hypercapnia may aggravate neuronal injury by extra- and intra-cellular acidification and/or imp...Continue Reading

References

Jul 1, 1977·The Journal of Physiology·S R BloomR N Hardy
Jul 1, 1976·Stroke; a Journal of Cerebral Circulation·M C LeeJ A Resch
Jun 17, 1992·European Journal of Pharmacology·E SannaG Biggio
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·P M Kochanek, J M Hallenbeck
Dec 1, 1990·Journal of Neuroimmunology·E N BenvenisteG M Fuller
Aug 1, 1990·Journal of Internal Medicine·T Olsson
Sep 30, 1988·Biochemical and Biophysical Research Communications·Y NaitohH Imura
Nov 1, 1980·Intensive Care Medicine·H H Delooz
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·Y NakagawaN Nakamura
Jan 1, 1981·Stroke; a Journal of Cerebral Circulation·Y NakagawaW Feindel
Aug 1, 1995·Stroke; a Journal of Cerebral Circulation·E TarkowskiA Tarkowski
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·X WangG Z Feuerstein
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KatsuraB K Siesjö
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·G MastorakosJ S Weber
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·T SimilowskiJ P Derenne
Mar 20, 1997·Journal of the Neurological Sciences·A JohanssonM Fagerlund
Jan 1, 1997·Free Radical Biology & Medicine·W A PryorG L Squadrito
Jul 1, 1997·The Journal of Clinical Endocrinology and Metabolism·G PäthW A Scherbaum
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J AronowskiJ C Grotta
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A LoddickN J Rothwell
Sep 19, 1998·Free Radical Biology & Medicine·G L Squadrito, W A Pryor
Oct 13, 1998·Research in Veterinary Science·P M Taylor
Oct 13, 1998·In Vitro Cellular & Developmental Biology. Animal·S J VitkusD W McGee
Nov 7, 1998·Brain Research·H JørgensenJ Warberg
Nov 7, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·S T KaehlerA Philippu
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SuzukiY Fukuuchi

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Citations

Jul 23, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Darioush Savadi OskoueiEhsan Sharifipour
Oct 11, 2011·Journal of Neuroscience Methods·Yuki MurakamiFrank C Tortella
Apr 23, 2015·British Poultry Science·Q TongT G M Demmers
May 8, 2016·Resuscitation·Ahmad Abu-Arafeh, Peter Jd Andrews
Jan 17, 2014·Expert Review of Neurotherapeutics·Nada El Husseini, Daniel T Laskowitz
Apr 30, 2020·Current Opinion in Critical Care·Glenn M Eastwood, Alistair Nichol
Nov 14, 2018·Intensive Care Medicine·M B SkrifvarsGiuseppe Ristagno
Feb 11, 2011·Expert Review of Neurotherapeutics·Mira Katan, Mitchell S V Elkind

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