The Potential Role of Contraction-Induced Myokines in the Regulation of Metabolic Function for the Prevention and Treatment of Type 2 Diabetes

Frontiers in Endocrinology
Brian P Carson

Abstract

Skeletal muscle represents the largest organ in the body, comprises 36-42% of body weight, and has recently been recognized as having an endocrine function. Proteins expressed and released by muscle that have autocrine, paracrine, and endocrine bioactivities have been termed myokines. It is likely that muscle contraction represents the primary stimulus for the synthesis and secretion of myokines to enable communication with other organs such as the liver, adipose tissue, brain, and auto-regulation of muscle metabolism. To date, several hundred myokines in the muscle secretome have been identified, a sub-population of which are specifically induced by skeletal muscle contraction. However, the bioactivity of many of these myokines and the mechanism through which they act has either not yet been characterized or remains poorly understood. Physical activity and exercise are recognized as a central tenet in both the prevention and treatment of type 2 diabetes (T2D). Recent data suggest humoral factors such as muscle-derived secretory proteins may mediate the beneficial effects of exercise in the treatment of metabolic diseases. This mini-review aims to summarize our current knowledge on the role of contraction-induced myokines in me...Continue Reading

References

Jun 16, 2001·Journal of Applied Physiology·D C NiemanM Shute
Jul 9, 2002·Diabetes, Obesity & Metabolism·A TsuchidaH Noguchi
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Adam SteensbergBente Klarlund Pedersen
Jan 2, 2003·The Journal of Physiology·Jørn W HelgeErik A Richter
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Gerrit van HallBente K Pedersen
Nov 12, 2003·Journal of Muscle Research and Cell Motility·B K PedersenB Saltin
Sep 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·E W PetersenB K Pedersen
Jul 12, 2005·Exercise and Sport Sciences Reviews·Mark A Febbraio, Bente K Pedersen
Sep 2, 2006·Molecular Endocrinology·Lubna Al-KhaliliAnna Krook
Dec 23, 2006·Neurobiology of Learning and Memory·Bernward WinterStefan Knecht
Apr 7, 2007·Medicine and Science in Sports and Exercise·Lee T FerrisChwan-Li Shen
Feb 2, 2008·Obesity·Vanessa AlmendroFrancisco J López-Soriano
Apr 2, 2008·Medicine and Science in Sports and Exercise·Itamar LevingerSteve Selig
Nov 1, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T SchifferH K Strüder
Nov 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Lebris S QuinnJosép M Argilés
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Matthew J PotthoffShawn C Burgess
Aug 27, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jing XuMurielle M Véniant
May 15, 2010·European Journal of Applied Physiology·Maaike GoekintRomain Meeusen
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Emil WolskGerrit van Hall
Nov 6, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Rojas VegaH K Strüder
Dec 24, 2010·The Journal of Experimental Biology·Bente Klarlund Pedersen
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Fredirick L MashiliAnna Krook
Feb 22, 2012·The Journal of Biological Chemistry·Marcus M SeldinG William Wong
Jun 16, 2012·PloS One·Daniel Cuevas-RamosCarlos A Aguilar-Salinas
Jul 4, 2012·Archives of Gerontology and Geriatrics·Flávia Gomes de Melo CoelhoRuth Ferreira Santos-Galduróz
Jan 31, 2013·European Journal of Applied Physiology·Tore ChristiansenBjørn Richelsen
Feb 20, 2013·Archives of Physiology and Biochemistry·Sven W GörgensJürgen Eckel
Apr 23, 2013·Scandinavian Journal of Medicine & Science in Sports·T HuangL B Andersen
May 15, 2013·PloS One·Kook Hwan KimMyung-Shik Lee
Aug 9, 2013·American Journal of Physiology. Cell Physiology·Mika SchelerCora Weigert
Sep 3, 2013·Physiology·Carmen Fiuza-LucesAlejandro Lucia

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Citations

Dec 7, 2017·American Journal of Physiology. Endocrinology and Metabolism·Jonathan P Barlow, Thomas P Solomon
Nov 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hye Jeong LeeHyeon Soo Kim
Apr 16, 2019·Frontiers in Physiology·Rosanna Piccirillo
Feb 15, 2019·Frontiers in Physiology·Jong Han Lee, Hee-Sook Jun
Oct 8, 2020·Food & Function·Chantal Gauze-GnagneEric Badia
Sep 2, 2019·Experimental Gerontology·Hélio J Coelho-JuniorEmanuele Marzetti
Mar 7, 2021·Fundamental & Clinical Pharmacology·Nabil Foudi, Samuel Legeay
Aug 27, 2021·Journal of Applied Physiology·Andrew M StrohScott W Trappe

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Methods Mentioned

BETA
ELISA
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