The potential role of exosomes in the diagnosis and therapy of ischemic diseases

Cytotherapy
Wenting WangJuan Feng

Abstract

In the past, exosomes have been thought of as cellular dust. Today, they are thought to be carriers of real biomarkers and intercellular biological information. The composition of exosomes differs according to their source, and the subsequent information they carry, such as protein, microRNA or mRNA, may also be different. Recent studies have demonstrated that exosomes in ischemic diseases can help to make an early diagnosis, and in cellular experiments and animal models, exosomes promote angiogenesis, restrain cell apoptosis and reduce inflammation, among other actions, to protect ischemic organs. There is evidence that these protective effects are related to microRNAs in exosomes. In this review, we discuss the use of exosomes for early diagnosis of ischemic diseases and recent advances in the therapeutic use of exosomes in cell and mammalian models of ischemic diseases.

Citations

May 19, 2019·Circulation. Genomic and Precision Medicine·Farnaz Shoja-TaheriMichael E Davis
Jul 10, 2019·Restorative Neurology and Neuroscience·T L MooreB Buller
Jun 10, 2020·Molecular Biology Reports·Man-Man WangFeng Zhang
Jan 17, 2021·Molecular Diagnosis & Therapy·Ghada YousifAshfaq Shuaib
Aug 5, 2021·Stroke; a Journal of Cerebral Circulation·Jacopo BurrelloCarlo W Cereda

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