The Potential Role of Fatty Acids in Treating Diabetic Neuropathy

Current Diabetes Reports
M A Yorek

Abstract

This review will summarize recent findings of the effect of supplemental fatty acids, with an emphasis on omega-3 polyunsaturated fatty acids, as a treatment for diabetic peripheral neuropathy. Pre-clinical studies have provided evidence that treating diabetic rodents with δ linolenic acid (omega-6 18:3) and to a greater extent with eicosapentaenoic and docosahexaenoic acids (omega-3 20:5 and 22:6, respectively) improve and even reverse vascular and neural deficits. Additional studies have shown resolvins, metabolites of eicosapentaenoic and docosahexaenoic acids, can induce neurite outgrowth in neuron cultures and that treating type 1 or type 2 diabetic mice with resolvin D1 or E1 provides benefit for peripheral neuropathy similar to fish oil. Omega-3 polyunsaturated fatty acids derived from fish oil and their derivatives have anti-inflammatory properties and could provide benefit for diabetic peripheral neuropathy. However, clinical trials are needed to determine whether this statement is true.

References

May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·G A Jamal, H Carmichael
Oct 1, 1988·The Journal of Diabetic Complications·P O Julu
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rodolfo R Brenner
Jan 28, 2005·The New England Journal of Medicine·Solomon TesfayeUNKNOWN EURODIAB Prospective Complications Study Group
Mar 6, 2007·Trends in Immunology·Amiram Ariel, Charles N Serhan
Oct 4, 2007·American Journal of Physiology. Endocrinology and Metabolism·Irina G ObrosovaMark A Yorek
Nov 19, 2008·Nature Clinical Practice. Neurology·Rayaz A Malik
Apr 2, 2009·Clinical and Translational Science·Allison B GoldfineSteven E Shoelson
Jul 15, 2009·British Journal of Pharmacology·Payal Kohli, Bruce D Levy
Oct 3, 2009·Investigative Ophthalmology & Visual Science·M Soledad CortinaHaydee E P Bazan
Mar 17, 2010·Annals of Internal Medicine·Allison B GoldfineUNKNOWN TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team
May 15, 2010·Molecular Neurobiology·R Palacios-PelaezNicolas G Bazan
May 27, 2010·Diabetes/metabolism Research and Reviews·Eric P DavidsonMark A Yorek
Jul 1, 2010·The New England Journal of Medicine·UNKNOWN ACCORD Study GroupLawrence J Fine
Feb 23, 2011·The Ocular Surface·Nicola PritchardNathan Efron
May 9, 2012·Current Diabetes Reports·Nikolaos Papanas, Dan Ziegler
Jan 3, 2013·Current Pharmaceutical Design·Tamás VárkonyiPeter Kempler
May 30, 2013·World Journal of Gastroenterology : WJG·Wen-Shan LvMing Zheng
Jun 6, 2013·American Journal of Physiology. Endocrinology and Metabolism·Sergey LupachykMark A Yorek
Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Asieh Hosseini, Mohammad Abdollahi
Jul 3, 2013·Annals of Internal Medicine·Allison B GoldfineUNKNOWN Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
Aug 31, 2013·Molecular Neurobiology·Jiyin Zhou, Shiwen Zhou
Jan 11, 2014·Journal of Chemical Neuroanatomy·Rafet OzayCansel Turkay
Apr 2, 2014·Diabetes/metabolism Research and Reviews·Roman StavniichukMark A Yorek

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