The potential role of HGF-MET signaling and autophagy in the war of Alectinib versus Crizotinib against ALK-positive NSCLC

Journal of Experimental & Clinical Cancer Research : CR
Xing Huang

Abstract

Non-small-cell lung cancer (NSCLC) is currently the leading cause of cancer-related death. Accumulating evidences suggest that overcoming the therapeutic resistance in NSCLC is a big challenge. Recently, the outcomes of two independent phase 3 trials regarding Alectinib versus Crizotinib in ALK-positive NSCLC are encouraging. However, given the potential relevance of HGF-MET signaling and especially autophagy to the war against ALK-positive NSCLC between Alectinib and Crizotinib, it's too early to reach a convincing conclusion. Therefore, to further improve the therapeutic efficacy of ALK-positive NSCLC, this commentary highlights the negligence in design of relevant clinical trials, emphasizes the importance of molecular characteristics investigation, and discusses the prospect of combination therapy.

References

May 19, 2011·Nature Reviews. Clinical Oncology·Filip JankuRazelle Kurzrock
Nov 21, 2014·Cancer Research·Alessandro FurlanDavid Tulasne
May 20, 2015·Nature·Veronica FinisguerraMassimiliano Mazzone
Jun 7, 2017·The New England Journal of Medicine·Solange PetersUNKNOWN ALEX Trial Investigators
Jul 29, 2017·Nature Reviews. Cancer·Jean M Mulcahy LevyAndrew Thorburn

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Citations

Aug 18, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Yu-Shui MaDa Fu
Mar 3, 2020·Frontiers in Aging Neuroscience·P B Tirupathi PichiahShanmugam Achiraman
Feb 12, 2020·Cell Death & Disease·Hengyi ChenYong He
Aug 9, 2020·Signal Transduction and Targeted Therapy·Xing HuangTingbo Liang

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