Abstract
Studies indicate that, among a number of other cytokines, interferons (IFN alpha, beta and gamma) are important elements regulating acute as well as chronic inflammatory responses. The role of interferons has been investigated in various experimental models of inflammation, by administration both of interferons and of antibodies that block the biological activity of interferons formed endogenously. The conclusions reached from these experiments clearly indicate that interferons can boost as well as inhibit inflammation. The effects depend on the type of inflammation studied, the time of interferon administration or emergence in the tissue, the type of interferon (alpha/beta or gamma), the dosage, and the presence of other inflammation-controlling cytokines. The effect of blockage of IFN gamma by the systemic administration of neutralising antibodies is particularly clear. Such blockage has been found to profoundly modify local lipopolysaccharide (LPS)-induced inflammation, brain inflammation due to autoimmunity or infection, and shock reactions caused by systemic administration of LPS. Further research on the particular place occupied by interferons in the inflammation-controlling cytokine network holds great promise, not only ...Continue Reading
Citations
Aug 21, 1992·Pharmaceutisch Weekblad. Scientific Edition·B C Takx-Köhlen
Jun 15, 1989·Experientia·G OpdenakkerJ Van Damme
Jun 21, 1991·Biochemical Pharmacology·E T Morgan
Nov 1, 1992·Neuroscience·K SaitoM P Heyes
Jul 21, 2006·Journal of Toxicology and Environmental Health. Part a·Takamichi IchinoseTakayuki Shibamoto
Dec 1, 1992·Journal of Interferon Research·J HeymerW Leibold
Apr 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G M BahrL A Chedid
Mar 14, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Massimo Amadori
Dec 1, 1991·European Journal of Clinical Investigation·A Billiau, F Vandekerckhove
Sep 9, 2011·Clinical and Vaccine Immunology : CVI·Shawn S JacksonNorman L Letvin
Jul 16, 2010·Journal of Leukocyte Biology·Christopher R RomeroEdward R Sherwood
Jan 1, 1992·Rheumatology International
Mar 22, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Manpreet Kaur SainiSankar Nath Sanyal
Jul 15, 1992·Biochemical and Biophysical Research Communications·F E RomantsevI I Votrin
Nov 2, 2005·Redox Report : Communications in Free Radical Research·Alexandra StolzingTilman Grune
Jul 10, 2012·Experimental and Molecular Pathology·Tiesuo HanFeng Gao
Jul 31, 2013·Neuropharmacology·Jin A KimJin Tae Hong
Jul 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S YoonM H Hirata