PMID: 16524352Mar 10, 2006Paper

The potential role of ketamine in hospice analgesia: a literature review

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
Justin LeggeDavid P Elliott

Abstract

The objective of this review is to examine the role of ketamine as an analgesic for palliative treatment in the hospice care setting. The sources referenced in this review were found September 22, 2005, via an Internet search of the MEDLINE database and Cochrane Database of Systematic Reviews. Search terms included analgesia, cancer pain, dextromethorphan, hospice, ketamine, opioids, palliative care, neuropathic pain, and morphine. Articles and case reports were included that relate to ketamine use as an analgesic agent and not as an anesthetic. Because of patient variability with ketamine use and dosing, focus was placed on analgesic benefit versus no analgesic benefit. Because of the lack of controlled trials, application of all analgesic data related to ketamine use was relevant to this review. The strength of evidence is currently moderate, but the available trials and reports reviewed in this paper describe compelling results. Ketamine has been effective in producing analgesia in patients receiving palliative care, especially when used in combination with opioids. When opioid therapy is no longer sufficient to improve quality of life in the hospice setting, the addition of ketamine may be considered as adjunctive therapy.

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Citations

May 17, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Karen E Binkley
Jun 15, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Kathirvel SubramaniamRichard A Steinbrook
Aug 24, 2010·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Shoshana ChazanAvi A Weinbroum
May 31, 2015·Journal of Intensive Care Medicine·Vivek K MoitraHannah Wunsch
Apr 17, 2012·The American Journal of Hospice & Palliative Care·Irene ConnollyMarcos Montagnini
Jun 10, 2010·Current Opinion in Anaesthesiology·Jan Persson
Apr 16, 2019·The Clinical Journal of Pain·Robert B WindsorAnnette Anderson

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