The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers

Archivum Immunologiae Et Therapiae Experimentalis
Chon-Kit ChouChien-Chih Chiu

Abstract

Gli-similar 3 (Glis3) belongs to a Glis subfamily of Krüppel-like zinc-finger transcription factors characterized to regulate a set of downstream targets essential for cellular functions, including pancreatic development, β-cell maturation and maintenance, and insulin production. Examination of the DNA-binding domain of Glis3 reveals that this domain contains a repeated cysteine 2/histidine 2 (Cys2/His2) zinc-finger motif in the central region where the recognized DNA sequence binds. The loss of the production of pancreatic hormones, such as insulin 1 and 2, is linked to the down-regulation of β cells-related genes and promotes the apoptotic death of β cells found in mutant Glis3. Although accumulating studies converge on the Glis3 functioning in β cells, recently, there have been developments in the field of Glis3 using knockdown/mutant mice to better understand the role of Glis3 in diseases. The Glis3 mutant mice have been characterized for their propensity to develop congenital hypothyroidism, polycystic kidney disease, and some types of cancer. In this review, we attempt to comprehensively summarize the knowledge of Glis3, including its structure and general function in cells. We also collected and organized the academic ac...Continue Reading

References

Feb 28, 1998·The EMBO Journal·L O'ConnorD C Huang
Feb 13, 2001·Biochemical and Biophysical Research Communications·K YamamotoY Ohtake
Oct 9, 2002·The Journal of Biological Chemistry·Kohsuke KataokaHiroshi Handa
Mar 7, 2003·Genome Biology·Joanna KaczynskiRaul Urrutia
Feb 1, 2007·Acta Neuropathologica·Inna Lukashova-v ZangenWolfgang Roggendorf
Oct 2, 2007·The International Journal of Biochemistry & Cell Biology·Richard PearsonShisan Bao
Jan 30, 2008·Molecular and Cellular Biology·Yong-Sik KimAnton M Jetten
Feb 7, 2008·Cell Biochemistry and Biophysics·Kathryn J Brayer, David J Segal
Feb 12, 2008·Nucleic Acids Research·Ju Youn BeakAnton M Jetten
Jun 3, 2008·Trends in Genetics : TIG·N Henriette Uhlenhaut, Mathias Treier
Jul 5, 2008·Development·Huajing WanJeffrey A Whitsett
Mar 11, 2009·Molecular and Cellular Biology·Hong Soon KangAnton M Jetten
Jun 2, 2009·FEBS Letters·Naoki WatanabeHisashi Hashimoto
Dec 17, 2009·Histopathology·Maria V Yusenko, Gyula Kovacs
Jun 12, 2010·Orphanet Journal of Rare Diseases·Maynika V Rastogi, Stephen H LaFranchi
Dec 9, 2010·European Journal of Endocrinology·P DimitriJ W Gregory
Mar 7, 2012·Vitamins and Hormones·Kristin Lichti-KaiserAnton M Jetten
May 17, 2012·Cold Spring Harbor Perspectives in Biology·Cecil M BenitezSeung K Kim
Nov 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sorin Fedeles, Anna Rachel Gallagher
Aug 15, 2014·Human Molecular Genetics·Lei XuJulien Sage

❮ Previous
Next ❯

Citations

May 10, 2020·International Journal of Cancer. Journal International Du Cancer·Thais BasiliJorge S Reis-Filho
Dec 5, 2019·Thyroid : Official Journal of the American Thyroid Association·Giuditta RuraleLuca Persani
Mar 18, 2021·The Application of Clinical Genetics·Altaf A Kondkar

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
co-immunoprecipitation

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.