The potential role of miRNAs in multiple myeloma therapy

Expert Review of Hematology
Daniele CaraccioloPierfrancesco Tassone

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that are crucial players as post-transcriptional regulators of messenger RNAs (mRNAs). miRNA deregulation has been associated to the pathogenesis of several human malignancies, since they might potentially regulate relevant pathways involved in cancer onset and progression. Therefore, targeting the miRNA network could represent a promising therapeutic strategy for human cancer. Area covered: This review summarizes recent findings on miRNAs as therapeutics or therapeutic targets against multiple myeloma (MM) and its microenvironment, including the challenges to overcome in the next future for the clinical application of this innovative therapeutic approach. Expert commentary: The rising body of advanced preclinical evidence on the biological activity of miRNAs in the pathobiology of MM strongly supports the therapeutic potential of treatment for this still incurable disease. However, translation of this therapeutic strategy for MM patients requires the development of optimized delivery systems and efficient integration of 'omics' data with clinical evidence, to precisely identify MM patients who may benefit from a novel miRNA-based therapy.

References

Aug 29, 2002·The EMBO Journal·Yoontae LeeV Narry Kim
Mar 17, 2004·PLoS Biology·György HutvágnerPhillip D Zamore
Oct 20, 2004·Biochemistry·Birte Vester, Jesper Wengel
Jun 30, 2005·Journal of Bone and Mineral Metabolism·Brendan F BoyceLianping Xing
Jun 2, 2007·Molecular Cell·Tsung-Cheng ChangJoshua T Mendell
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Aug 23, 2008·Cell Cycle·Shan DengLin Zhang
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Flavia PichiorriCarlo M Croce
Apr 30, 2009·Blood·Aldo M RoccaroIrene M Ghobrial
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Jan 26, 2011·Annual Review of Pathology·Kenneth C Anderson, Ruben D Carrasco
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 18, 2011·Biochimica Et Biophysica Acta·Ying Poi Liu, Ben Berkhout
Jul 8, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nicola GiulianiSabrina Bonomini
Nov 15, 2011·Methods in Molecular Biology·Sinéad M Smith, David W Murray
Apr 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carlos Fernández de LarreaJoan Bladé
Jun 8, 2012·Current Cancer Drug Targets·P TagliaferriP Tassone
Oct 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria T Di MartinoPierfrancesco Tassone
Oct 27, 2012·Oncotarget·Nicola AmodioPierfrancesco Tassone
Mar 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emanuela LeonePierfrancesco Tassone
Mar 13, 2013·Oncotarget·Maria Teresa Di MartinoPierfrancesco Tassone
Mar 29, 2013·The New England Journal of Medicine·Harry L A JanssenMichael R Hodges
Apr 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marta LionettiAntonino Neri
Jun 7, 2013·Expert Opinion on Biological Therapy·Gabriella MissoMichele Caraglia

❮ Previous
Next ❯

Citations

Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Verena Theis, Carsten Theiss
Feb 13, 2020·Journal of Cellular and Molecular Medicine·Xianjuan ShenShaoqing Ju
Mar 23, 2019·Journal of Hematology & Oncology·Maria CucèCirino Botta
Apr 4, 2021·Cancers·Daniele CaraccioloPierfrancesco Tassone
Apr 4, 2021·Cancers·Maria Teresa Di MartinoPierfrancesco Tassone
Mar 9, 2020·Molecular Therapy. Nucleic Acids·Maria Teresa Di MartinoPierfrancesco Tassone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.