The potential role of myostatin and neurotransmission genes in elite sport performances

Journal of Biosciences
Laura FilonziF Nonnis Marzano

Abstract

Elite athletes are those who represent their sport at such major competition as the Olympic Games or World contests. The most outstanding athletes appear to emerge as a result of endogenous biologic characteristics interacting with exogenous influences of the environment, often described as a 'Nature and Nurture' struggle. In this work, we assessed the contribution given by 4 genes involved in muscles development (MSTN) and behavioural insights (5HTT, DAT and MAOA) to athletic performances. As for neurotransmission, 5HTT, DAT and MAOA genes have been considered as directly involved in the management of aggressiveness and anxiety. Genotypes and allelic frequencies of 5HTTLPR, MAOA-u VNTR, DAT VNTR and MSTN K153R were determined in 50 elite athletes and compared with 100 control athletes. In this work we found a significant correlation between the dopamine transporter genotype 9/9 and allele 9 and elite sport performances. On the contrary, no association was found between muscle development regulation or serotonin pathway and elite performances. Our data, for the first time, suggest a strong role of dopamine neurotransmitter in determining sport success, highlighting the role of emotional control and psycological management to re...Continue Reading

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Citations

Jan 29, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Cemil ÇelikÖzcan Uzun
May 30, 2020·European Journal of Sport Science·Alexander B T McAuleyAdam L Kelly
Jun 3, 2021·Genes·Valentina GinevičienėAlgirdas Utkus
Jul 3, 2021·Diagnostics·Kristina A MalsagovaAnna L Kaysheva

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