The potential role of pain-related SSEPs in the early prognostication of long-term functional outcome in post-anoxic coma

European Journal of Physical and Rehabilitation Medicine
Alessandra Del FelicePaolo Zanatta

Abstract

Cardiac arrest (CA) is a common cause of disability. Multimodal evaluation has improved prognosis but precocious biomarkers are not appropriate in determining long-term functional outcome. To identify early prognostication markers of long-term functional outcome in post-anoxic coma. Retrospective assessment of outcomes. Individuals older than 18 years with post-anoxic coma hospitalized in intensive care units after cardiac arrest (CA) regardless of cause (cardiac or non-cardiac) and location of event (in or out-of-hospital). Clinical, biological and neurophysiological data were collected within 48 hours from CA. Clinical data included time of no and low flow, CA rhythm, pupillary reflex, Glasgow motor score at admission and hyperthermia. Biological marker was the highest creatinine level. Neurophysiological parameters included EEG pattern and reactivity, Somatosensory Evoked Potential (SSEP), and Middle-Latency (ML) SSEP evoked at low (10 mA) and high (50 mA) intensity stimulation. Level of Cognitive Functioning Scale (LCFS), Disability Rating Scale and recovery from coma (Revised coma Recovery Scale [CRS-R]) were collected at 12 months. A LASSO multiple regression analysis was fitted to data to investigate the best predictors ...Continue Reading

Citations

Sep 13, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A ComanducciM Massimini
Oct 21, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Stefano MasieroAlessandra Del Felice

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