PMID: 6410946Aug 1, 1983Paper

The potential role of respiratory therapy equipment in cross infection. A study using a canine model for pneumonia

The American Review of Respiratory Disease
K L ChristopherW Conway

Abstract

Experimental Pseudomonas aeruginosa pneumonia was induced in 8 dogs that had radiation-induced leukopenia. Three dogs were supported by mechanical ventilation (MV), 3 received continuous heated aerosol therapy (CHAT), and 2 did not receive respiratory therapy and served as control animals. The animals were studied in a carefully controlled environment until they succumbed to infection or they were killed at 24 h. An air sampler was used to collect exhaled P. aeruginosa aerosols at distances as far as 15 feet from the dogs at multiple time intervals. Water condensate in the tubing of MV and CHAT equipment was collected and cultured at the same intervals. Results showed that all dogs had multilobar P. aeruginosa pneumonia at necropsy. Control dogs did not exhale aerosols containing P. aeruginosa. Animals that were supported by MV, exhaled contaminated aerosols, but organisms could not be recovered at distances greater than 2 feet. In contrast, aerosols containing P. aeruginosa were recovered at distances as far as 15 feet from the animals receiving CHAT. Furthermore, as much as 1L of water condensate was collected in a 24-h period from tubing associated with MV and CHAT. Although the nebulizers and humidifiers remained sterile, t...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.