The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression.

Genes
Joanna Patrycja WróblewskaAndrzej Marszałek

Abstract

Uveal melanoma (UM) is the most common primary tumor of the eye diagnosed in adults, associated with a high risk of metastasis and thereby, poor prognosis. Among known risk factors for the development of metastatic disease is the loss of BAP1 expression and chromosome 3 monosomy in the primary tumor. However, the expression levels of specific micro RNAs (miRNA) in tumor tissue may also serve as a valuable marker for determining the risk of metastatic disease in patients with primary uveal melanoma. In our study, we analyzed the miRNA expression data of cases selected from The Cancer Genome Atlas study on uveal melanoma, and determined a panel of 15 miRNAs differentially expressed between patients with primary and metastatic disease. Next, 6 miRNAs were validated on a group of 46 tumor samples from primary and metastatic patients. We have shown, that expression of hsa-miR-592, hsa-miR-346, and hsa-miR-1247 was significantly increased, while hsa-miR-506 and hsa-miR-513c were decreased in the tumors of patients with metastatic disease. Hsa-miR-196b expression did not differ between the two subgroups, however, we showed significant correlation with BAP1 expression. Moreover, hsa-miR-592 also showed correlation with monosomy 3 tumor...Continue Reading

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Citations

Aug 13, 2020·Cellular and Molecular Life Sciences : CMLS·Chun YangPierre Hardy
Aug 13, 2020·International Journal of Molecular Sciences·Karen AughtonSarah E Coupland
Jul 3, 2021·Biomedicines·Luis Javier Martínez-GonzálezMaría Jesus Alvarez-Cubero

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Methods Mentioned

BETA
PCR
deubiquitination

Software Mentioned

Image Analysis
GraphPad Prism
microT
LightCycler 480
CDS
Bioconductor edgeR package
miRDB
TCGA
GraphPad
TargetScan

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