The potential role of thrombopoietin in idiopathic thrombocytopenic purpura

Blood Reviews
A von dem BorneM de Haas

Abstract

Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article.

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Citations

Nov 30, 2007·The New England Journal of Medicine·James B BusselJulian M Jenkins
Dec 2, 2004·Expert Opinion on Pharmacotherapy·S Gerald Sandler, S Osman Tutuncuoglu
May 5, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Baolai HuaYongqiang Zhao
Nov 23, 2013·Frontiers of Medicine·Xinguang LiuJun Peng
Dec 3, 2014·Internal Medicine·Teruhiko YoshidaSadamu Okada
Mar 27, 2003·European Journal of Haematology·Jokke HannukselaWilliam S Sly
Dec 16, 2017·European Journal of Haematology·Jacopo Agnelli GiacchelloAlessandra Borchiellini

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