PMID: 8958942Oct 31, 1996Paper

The potential therapeutic role of interleukin-12 in cutaneous T-cell lymphoma

Annals of the New York Academy of Sciences
A H RookG Trinchieri

Abstract

Cutaneous T-cell lymphoma (CTCL) is a lymphoproliferative disorder characterized by skin invasion of clonally derived malignant CD4+ lymphocytes that phenotypically resemble mature T-helper (Th) cells. Sezary syndrome (SzS) represents an advanced form of CTCL associated with generalized erythroderma and involvement of the peripheral blood by the malignant cell population. We have previously demonstrated aberrant cytokine production by peripheral blood mononuclear cells (PBMCs) in SzS characterized by increased IL-4 and deficient IL-2 and IFN-gamma production, as well as increased expression of mRNA for IL-4 and IL-5 within active skin lesions, indicating that the clonal T-cell population is likely derived from the T-helper type 2 (Th2) subset of helper T lymphocytes. Furthermore, a variety of immune abnormalities have been observed in association with SzS that have been attributed to the cytokine abnormalities. Because IL-12 is a potent inducer of IFN-gamma production and causes the activation of cytotoxic lymphocytes, we assessed the production of IL-12 by PBMCs from SzS patients, and whether IL-12 could alter the unfavorable cytokine balance typical of SzS and, thus, possibly lead to correction of immune defects. In this revi...Continue Reading

References

Feb 1, 1991·Journal of the American Academy of Dermatology·R M KnoblerM Micksche
Feb 1, 1981·The Journal of Clinical Investigation·B F HaynesA S Fauci
Feb 1, 1980·Journal of the American Academy of Dermatology·R L Edelson
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately

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Citations

Apr 21, 2005·The Journal of Clinical Investigation·Ellen J KimAlain H Rook
Apr 30, 2002·American Journal of Clinical Dermatology·Narin ApisarnthanaraxMadeleine Duvic
Jun 30, 2004·Leukemia & Lymphoma·D A PichardoS T Rosen
Aug 30, 2008·The Journal of Investigative Dermatology·Nicolas DulphyAntoine Toubert
Jan 9, 2004·Hematology/oncology Clinics of North America·Werner KempfGünter Burg
Oct 5, 2015·Dermatologic Clinics·Auris O Huen, Ellen J Kim
Dec 23, 2003·Dermatologic Therapy·Chunlei Zhang, Madeleine Duvic
Jun 12, 2018·The Journal of Dermatological Treatment·Iris Amitay-LaishEmmilia Hodak
Oct 4, 2006·Dermatologic Therapy·Chunlei Zhang, Madeleine Duvic
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Andreas C HäffnerFrank Oliver Nestle
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R S SiegelT M Kuzel
Jun 20, 2018·Frontiers in Oncology·Kazuyasu Fujii
Nov 21, 2007·International Reviews of Immunology·Takaomi Sanda
Jul 22, 2020·International Archives of Allergy and Immunology·Malgorzata BobrowiczEmmanuella Guenova

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