The potential value of (Myo)fibroblastic stromal reaction in the diagnosis of prostatic adenocarcinoma

The Prostate
Davor Tomas, Bozo Kruslin

Abstract

Reactive stromal changes that occur in different human cancers probably are involved in local tumor spreading. The aim of this study was to analyze changes of the stroma in prostatic carcinoma and to establish their possible diagnostic significance. For the definition of reactive stroma in prostate cancer Mallory trichrome method and immunohistochemical analysis of vimentin, alpha-smooth muscle actin, and desmin were performed. Compared with adjacent peritumoral tissue and stroma in benign prostatic hyperplasia, reactive stroma in prostate cancer showed increased vimentin expression, and decreased desmin expression (P < 0.05). Mallory method also showed more pronounced desmoplastic reaction in stroma of prostatic adenocarcinoma (P < 0.05). Our study indicates that a reactive stroma, which occurs in prostatic carcinoma, could be clearly shown by Mallory method and confirmed by immunohistochemistry. We suggest that Mallory trichrome method may be used as a helpful additional diagnostic tool in the diagnosis of suspicious cases of prostatic adenocarcinoma.

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Citations

Dec 27, 2006·Pathology Oncology Research : POR·Bozo KruslinMladen Belicza
Apr 17, 2008·Pathology Oncology Research : POR·Tatjana BujasDavor Tomas
Sep 14, 2011·Pathology Oncology Research : POR·Wagner José FávaroValéria Helena A Cagnon
Sep 13, 2011·Pathology Oncology Research : POR·Monika UlamecBožo Krušlin
May 3, 2006·Prostate Cancer and Prostatic Diseases·D TomasB Kruslin
Feb 15, 2007·Journal of Clinical Pathology·Monika UlamecBozo Kruslin
Dec 24, 2013·Histochemistry and Cell Biology·A C HetzlV H A Cagnon
May 6, 2014·Life Sciences·Larissa Akemi KidoValéria Helena Alves Cagnon
May 29, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S Etemad-MoghadamM Alaeddini
Apr 3, 2016·Tissue & Cell·Caroline Fernanda Sanches Dal PozzoValéria Helena Alves Cagnon
Sep 8, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Wenjin ChenDavid J Foran
Jan 17, 2016·Endocrine-related Cancer·Larissa Akemi KidoValeria Helena Alves Cagnon
Jul 7, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Antonio H DuarteCristiane F Ramos
Feb 15, 2018·Cancer Cell International·Renato F IvanovicSabrina T Reis
Dec 22, 2005·American Journal of Physiology. Endocrinology and Metabolism·Hanh LeMarc R Blackman
May 13, 2010·Scandinavian Journal of Urology and Nephrology·Davor TomasBozo Kruslin
Nov 2, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie-France PenetZaver M Bhujwalla

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