The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

Stem Cells International
Judith GronbachHarald Ehrhardt

Abstract

Preponderance of proinflammatory signals is a characteristic feature of all acute and resulting long-term morbidities of the preterm infant. The proinflammatory actions are best characterized for bronchopulmonary dysplasia (BPD) which is the chronic lung disease of the preterm infant with lifelong restrictions of pulmonary function and severe consequences for psychomotor development and quality of life. Besides BPD, the immature brain, eye, and gut are also exposed to inflammatory injuries provoked by infection, mechanical ventilation, and oxygen toxicity. Despite the tremendous progress in the understanding of disease pathologies, therapeutic interventions with proven efficiency remain restricted to a few drug therapies with restricted therapeutic benefit, partially considerable side effects, and missing option of applicability to the inflamed brain. The therapeutic potential of mesenchymal stromal cells (MSCs)-also known as mesenchymal stem cells-has attracted much attention during the recent years due to their anti-inflammatory activities and their secretion of growth and development-promoting factors. Based on a molecular understanding, this review summarizes the positive actions of exogenous umbilical cord-derived MSCs on ...Continue Reading

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Citations

Mar 7, 2020·Journal of Clinical Medicine·Judith BehnkeHarald Ehrhardt
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Noemi EiroFrancisco J Vizoso
May 30, 2019·Frontiers in Pediatrics·Frank OehmkeHarald Ehrhardt
Apr 6, 2019·Frontiers in Physiology·Frank van BelFloris Groenendaal
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Jan 28, 2021·International Journal of Molecular Sciences·Maurizio J GoetzHarald Ehrhardt
Apr 4, 2021·International Journal of Molecular Sciences·Silvia Fernández-FrancosFrancisco J Vizoso

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