The potentiation of B lymphocyte responses through CD2/LFA-3 interactions involving erythrocytes is IL2 independent.

Cellular Immunology
R TrifilettiG Virella

Abstract

The response of human B cells to pokeweed mitogen (PWM) stimulation is potentiated when autologous erythrocytes (E) are added to peripheral blood mononuclear cell (PBMC) cultures. This potentiation has been previously shown to be dependent on interactions between the CD2 molecule on T cells and the lymphocyte function-associated antigen 3 (LFA-3) expressed by autologous erythrocytes. Since in other experimental systems the activation of T cells by CD2/LFA-3 interactions has resulted in increased secretion of interleukin 2 (IL2), we were interested in studying the role of IL2 in PBMC cultures stimulated with PWM and autologous E. The addition of autologous E significantly depressed IL2 levels in PWM-stimulated PBMC cultures. This effect was not secondary to increased expression of IL2 receptors by activated cells, since the addition of anti-TAC antibodies did not result in a significant increase in measurable levels of IL2. The addition of anti-IL2 to PBMC failed to abrogate the potentiating effect of E and it actually further enhanced the production of IgM and IgG from cultures stimulated with PWM + E. These results suggest that the potentiation of B cell function induced by autologous E is not mediated by IL2, either directly ...Continue Reading

Citations

Oct 13, 2001·The Journal of Applied Psychology·M RotundoP R Sackett
Nov 1, 1992·European Journal of Immunology·T J DenglerS C Meuer
Jan 11, 2019·International Journal of Molecular Sciences·Guillaume PoirouxHervé Benoist

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