May 3, 2020

Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function

BioRxiv : the Preprint Server for Biology
P. C. GoddardE. G. Burchard


Bronchodilator drugs are commonly prescribed for treatment and management of impaired lung function from diseases such as asthma. Administration of bronchodilator medication can partially or fully restore lung function as measured by pulmonary function tests. The genetics of baseline lung function measures taken prior to bronchodilator medication has been heavily studied, and the genetics of the bronchodilator response itself has received some attention. However, the research on the genetics of post-bronchodilator lung function is less well understood. To address this research gap, we analyzed three pulmonary function traits in 1,103 subjects from the Study of African Americans, Asthma, Genes, and Environment (SAGE), a pediatric asthma case-control cohort, using an integrative genomic analysis approach that combined genotype, locus-specific genetic ancestry, and functional annotation information. Crucially, we coupled summary statistics from a genome-wide association study (GWAS) with an admixture mapping scan to analyze the same lung function measures taken both before and after albuterol bronchodilator administration on the same subjects. We identified 18 GWAS loci, and 5 additional loci from admixture mapping, spanning sever...Continue Reading

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