The power of hyphenated chromatography/time-of-flight mass spectrometry in public health laboratories

Journal of Agricultural and Food Chemistry
María IbáñezF Hernández

Abstract

Laboratories devoted to the public health field have to face the analysis of a large number of organic contaminants/residues in many different types of samples. Analytical techniques applied in this field are normally focused on quantification of a limited number of analytes. At present, most of these techniques are based on gas chromatography (GC) or liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS). Using these techniques only analyte-specific information is acquired, and many other compounds that might be present in the samples would be ignored. In this paper, we explore the potential of time-of-flight (TOF) MS hyphenated to GC or LC to provide additional information, highly useful in this field. Thus, all positives reported by standard reference targeted LC-MS/MS methods were unequivocally confirmed by LC-QTOF MS. Only 61% of positives reported by targeted GC-MS/MS could be confirmed by GC-TOF MS, which was due to its lower sensitivity as nonconfirmations corresponded to analytes that were present at very low concentrations. In addition, the use of TOF MS allowed searching for additional compounds in large-scope screening methodologies. In this way, different contaminants/residues not included in either...Continue Reading

References

Jul 25, 2003·Journal of Chromatography. a·Jens DallügeUdo A Th Brinkman
Dec 14, 2004·Rapid Communications in Mass Spectrometry : RCM·María IbáñezFélix Hernández
Mar 8, 2007·Analytical and Bioanalytical Chemistry·Stephen A Wise, Hendrik Emons
Jul 3, 2007·Journal of Mass Spectrometry : JMS·Tania PortolésFélix Hernández
Feb 2, 2008·Mass Spectrometry Reviews·Luigi MondelloGiovanni Dugo
May 21, 2008·Analytical and Bioanalytical Chemistry·A A M StolkerM W F Nielen
Apr 16, 2010·Journal of Chromatography. a·Ashok Kumar MalikYolanda Picó
Jun 18, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Juan C Domínguez-RomeroAntonio Molina-Díaz

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Citations

Jan 25, 2013·Journal of Agricultural and Food Chemistry·Jaime Nácher-MestreFélix Hernández
Jun 1, 2013·Journal of Mass Spectrometry : JMS·María IbáñezFélix Hernández
Oct 20, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shizuka Saito-ShidaHiroshi Akiyama
Jul 1, 2017·Biomedical Chromatography : BMC·Abdalla Ahmed Elbashir, Hassan Y Aboul-Enein
May 20, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shizuka Saito-ShidaHiroshi Akiyama

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