The power of the methods for detecting interlocus gene conversion.

Genetics
Sayaka P Mansai, Hideki Innan

Abstract

Interlocus gene conversion can homogenize DNA sequences of duplicated regions with high homology. Such nonvertical events sometimes cause a misleading evolutionary interpretation of data when the effect of gene conversion is ignored. To avoid this problem, it is crucial to test the data for the presence of gene conversion. Here, we performed extensive simulations to compare four major methods to detect gene conversion. One might expect that the power increases with increase of the gene conversion rate. However, we found this is true for only two methods. For the other two, limited power is expected when gene conversion is too frequent. We suggest using multiple methods to minimize the chance of missing the footprint of gene conversion.

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Citations

Dec 14, 2011·The Journal of Experimental Medicine·Jérémy ManryLluis Quintana-Murci
Dec 12, 2012·Molecular Biology and Evolution·Omar E CornejoMichael J Stanhope
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Sep 12, 2015·PloS One·Bryan KorithoskiBryan Kolaczkowski
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Jan 1, 2011·Genes·Sayaka P MansaiHideki Innan
Jan 1, 2011·Genes·J Roman Arguello, Tim Connallon
Jan 1, 2011·Genes·Jeffrey A Fawcett, Hideki Innan
Nov 10, 2017·Genome Biology and Evolution·Benjamin A SandkamFelix Breden
Nov 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Arbel HarpakJonathan K Pritchard
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