The power plant of the cell is also a smithy: the emerging role of mitochondria in cellular iron homeostasis

Annals of Medicine
Alex D Sheftel, Roland Lill

Abstract

Iron is required for a barrage of essential biochemical functions in virtually every species of life. Perturbation of the availability or utilization of iron in these functions or disruption of other components along iron-requiring pathways can not only lead to cellular/organismal insufficiency of respective biochemical end-products but also result in a broad derangement of iron homeostasis. This is largely because of the elaborate regulatory mechanisms that connect cellular iron utilization with uptake and distribution. Such mechanisms are necessitated by the 'double-edged' nature of the metal, whose very property as a useful biological catalyst also makes it able to generate highly toxic compounds. Since the majority of iron is dispatched onto a functional course by mitochondria-localized pathways, these organelles are in an ideal position within the cellular iron anabolic pathways to be a central site for regulation of iron homeostasis. The goal of this article is to provide an overview of how mitochondria acquire and use iron and examine the ramifications of disturbances in these processes on overall cellular iron homeostasis.

References

Nov 1, 1976·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G Sanchez-CasisA Barbeau
Apr 1, 1978·Physiological Reviews·H N Munro, M C Linder
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P D CotterD F Bishop
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Jul 14, 1989·Biochemical and Biophysical Research Communications·P D Drew, I Z Ades
Apr 1, 1988·The Biochemical Journal·P PonkaJ Martinez-Medellin
Feb 1, 1974·British Journal of Haematology·P Aisen
Nov 1, 1974·The Biochemical Journal·P M HarrisonR J Hoare
Nov 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·S S Botomley
May 29, 1981·Biochimica Et Biophysica Acta·T P TufanoK N Raymond
Jan 1, 1995·Progress in Nucleic Acid Research and Molecular Biology·B K MayS S Bottomley
Jan 18, 1994·Biochemistry·H A DaileyM K Johnson
Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Mar 14, 1997·Biochimica Et Biophysica Acta·D R Richardson, P Ponka
Nov 14, 1997·The Journal of Biological Chemistry·L Li, J Kaplan
Jun 20, 1998·The Journal of Biological Chemistry·L S GoesslingR E Thach
Jun 23, 1998·The Journal of Biological Chemistry·V PicardC Beaumont
Jul 11, 1998·The Journal of Biological Chemistry·S A KnightA Dancis
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·H LangeR Lill
Jun 6, 2000·The Journal of Biological Chemistry·N MitsuhashiS Seino
Aug 1, 2000·Trends in Biochemical Sciences·R Lill, G Kispal
Oct 18, 2000·The Journal of Biological Chemistry·J LiA Dancis
Apr 27, 2001·The Journal of Biological Chemistry·S LeviJ Drysdale
Jun 8, 2001·The Journal of Biological Chemistry·L LiJ Kaplan
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·J C RutherfordD R Winge
Feb 2, 2002·Human Molecular Genetics·Patrizia CavadiniGrazia Isaya
Mar 6, 2002·The Journal of Biological Chemistry·Yuko Yamaguchi-IwaiRyuzo Sasaki

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Citations

Feb 23, 2012·Biochemistry·Jennifer Bridwell-RabbDavid P Barondeau
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alex D SheftelRoland Lill
Oct 12, 2011·The Journal of Biological Chemistry·Ulrich MühlenhoffRoland Lill
Apr 26, 2013·Molecular Biology of the Cell·Marta A UzarskaUlrich Mühlenhoff
May 29, 2015·Biochemistry·Nicholas G FoxDavid P Barondeau
Jan 12, 2010·Trends in Endocrinology and Metabolism : TEM·Alex SheftelRoland Lill
Jun 28, 2015·European Journal of Cell Biology·Ulrich MühlenhoffRoland Lill
Jan 28, 2014·Biochimie·Oliver StehlingRoland Lill
May 9, 2012·Biochimica Et Biophysica Acta·Pamela M SmithDennis R Winge
Apr 23, 2010·The Biochemical Journal·Maya ShvartsmanZ Ioav Cabantchik
Jun 3, 2010·The Biochemical Journal·Marc MikhaelPrem Ponka
May 23, 2012·Biochimica Et Biophysica Acta·Roland LillUlrich Mühlenhoff
Dec 6, 2011·Biochimica Et Biophysica Acta·Pamela M SmithDennis R Winge
Aug 23, 2011·Biochimica Et Biophysica Acta·Alex D SheftelPrem Ponka
Jul 7, 2010·Cell·Matthias W HentzeClara Camaschella
Aug 3, 2010·Cell Metabolism·Bruno GalyMatthias W Hentze
Jun 16, 2016·Biochemistry. Biokhimii︠a︡·I V MiltoT K Klimenteva
Nov 6, 2018·Metallomics : Integrated Biometal Science·Matthias MisslingerHubertus Haas
Apr 25, 2019·Journal of Mass Spectrometry : JMS·Dušan VeličkovićChristopher R Anderton
Oct 20, 2011·The Plant Journal : for Cell and Molecular Biology·Steven PenfieldIan A Graham
Feb 22, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Maya Shvartsman, Z Ioav Cabantchik
Mar 13, 2012·Current Opinion in Hematology·Jacky ChungBarry H Paw
Dec 14, 2018·Cells·Chiara VolaniGuenter Weiss
Apr 25, 2019·Heart Failure Reviews·Mihai LupuGabriela Adriana Filip
Dec 15, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jiayin GaoLinxi Chen

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