The PR interval and QRS duration could be predictors of renal function decline

Atherosclerosis
Saori MajimaMichiaki Fukui

Abstract

Previous studies have implicated PR interval (iPR) and QRS duration (dQRS) obtained by electrocardiography in independent predictors of cardiovascular disease, which often precedes renal dysfunction. The aim of this study was to examine whether iPR or dQRS could be a predictor of renal function decline in a community-based cohort. We enrolled 1149 healthy subjects, and retrospectively evaluated the relationships between iPR or dQRS and renal function decline, observation period of which was 3 years, and assessed whether iPR or dQRS could predict renal function decline. The iPR (r=-0.102, p=0.0006) or dQRS (r=-0.097, p=0.0010) was negatively associated with a rate of decline in estimated glomerular filtration rate (eGFR). Multiple regression analyses revealed that iPR (β=-0.095, p=0.0023) or dQRS (β=-0.069, p=0.0351) was an independent determinant of the rate of decline in eGFR after adjustment for covariates. Logistic regression analyses demonstrated that the longest iPR (odds ratios (OR), 2.03; 95% confidence intervals (CI), 1.49 to 2.76; p<0.0001) or dQRS (OR, 1.62; 95% CI, 1.16 to 2.25; p=0.0043) tertile showed an increased OR for prevalence of the rate of decline in eGFR≤1 ml/min/1.73 m2/year compared to the shortest iPR or...Continue Reading

References

Apr 1, 1979·Mechanisms of Ageing and Development·F C YinM L Weisfeldt
Feb 1, 1975·Circulation Research·E G LakattaM L Weisfeldt
Oct 8, 1999·The New England Journal of Medicine·E Ritz, S R Orth
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Mar 13, 2003·Kidney International·Guruprasad ManjunathMark J Sarnak
Nov 1, 1964·The American Journal of Medicine·M LEV
May 22, 2004·Journal of the American Society of Nephrology : JASN·Julián SeguraLuis M Ruilope
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mahmut Ilker YilmazCarmine Zoccali
Jun 15, 2007·Archives of Internal Medicine·Essam F ElsayedDaniel E Weiner
Mar 10, 2009·Blood Purification·Robb KociolAndrew Shaw
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jun 25, 2009·JAMA : the Journal of the American Medical Association·Susan ChengThomas J Wang
Feb 18, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Arihiro KiyosueRyozo Nagai
Jan 1, 2009·F1000 Medicine Reports·Miet Schetz
Jun 23, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Mari SuzukiJunichiro Hayano
Feb 8, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yap-Hang ChanHung-Fat Tse
Jun 4, 2013·The American Journal of Cardiology·Apurva Omkar BadhekaMauricio Gabriel Cohen
Jun 1, 2014·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Peter FlueckigerRachel E Patzer

❮ Previous
Next ❯

Citations

Aug 8, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sofia SkampardoniPhilip A Kalra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.