The Practicality of Targeted Prostate Biopsy Procedures on the Dominant Side of the Tumor Determined by Magnetic Resonance Imaging in Elderly Patients with High Serum Levels of Prostate-Specific Antigen

The World Journal of Men's Health
Jung Sik HuhKyung Kgi Park

Abstract

To examine the possibility of reducing the number of cores per prostate biopsy in elderly patients with high levels of prostate-specific antigen (PSA) without significantly lowering the detection rate of prostate cancer. Two hundreds sixteen men with PSA levels >20 ng/mL who underwent prostate biopsies from May 2009 to April 2013 were retrospectively reviewed. With the help of magnetic resonance imaging (MRI), the laterality of the dominant tumor burden in patients was determined. The results of targeted biopsies were compared with those of conventional biopsy procedures. The mean age and PSA level were 79.5 years and 81.3 ng/mL, respectively, and the overall diagnostic rate of sextant biopsies was 81.9% (177/216). MRI was able to show the tumor burden in 189 of the 216 patients. The detection rate of transrectal ultrasonography (TRUS)-guided targeted biopsies was 87.3% (165/189). Detection rates were comparable with conventional biopsies (81.9% [177/216]) (p=0.23). Of the 177 men in whom the results of the sextant biopsy were positive, 12 men (6.8%) with PSA levels <29 ng/mL did not have any cancer cells according to targeted biopsies. However, all other patients were diagnosed with prostate cancer using the abovementioned tec...Continue Reading

References

Oct 22, 2010·Urologia Internationalis·Michael NomikosPrasad R Bollina
Nov 23, 2012·Journal of Magnetic Resonance Imaging : JMRI·Sofie IsebaertRaymond Oyen
Apr 25, 2013·Korean journal of urology·Katsumi ShigemuraMasuo Yamashita
Jul 24, 2013·Expert Review of Anticancer Therapy·Anastasios AnastasiadisTheo De Reijke
Oct 23, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julia WadeJenny L Donovan
Jan 1, 2012·Central European Journal of Urology·Adam MadejMarek Lipiński

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biopsy
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