The pre-BCR to the rescue: therapeutic targeting of pre-B cell ALL

Cancer Cell
Thomas Trimarchi, Iannis Aifantis

Abstract

Pre B-ALL is an aggressive cancer of the blood for which treatment of patients with relapsed and refractory disease remains a challenge. In this issue of Cancer Cell, Geng and colleagues surveyed the activation status of the pre-B cell receptor and comprehensively investigated downstream signaling mechanisms currently targetable with small molecule inhibitors.

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