The preanalytical optimization of blood cultures: a review and the clinical importance of benchmarking in 5 Belgian hospitals

Diagnostic Microbiology and Infectious Disease
Elise WillemsBilulu Study Group

Abstract

Bloodstream infections remain a major challenge in medicine. Optimal detection of pathogens is only possible if the quality of preanalytical factors is thoroughly controlled. Since the laboratory is responsible for this preanalytical phase, the quality control of critical factors should be integrated in its quality control program. The numerous recommendations regarding blood culture collection contain controversies. Only an unambiguous guideline permits standardization and interlaboratory quality control. We present an evidence-based concise guideline of critical preanalytical determinants for blood culture collection and summarize key performance indicators with their concomitant target values. In an attempt to benchmark, we compared the true-positive rate, contamination rate, and collected blood volume of blood culture bottles in 5 Belgian hospital laboratories. The true-positive blood culture rate fell within previously defined acceptation criteria by Baron et al. (2005) in all 5 hospitals, whereas the contamination rate exceeded the target value in 4 locations. Most unexpected, in each of the 5 laboratories, more than one third of the blood culture bottles were incorrectly filled, irrespective of the manufacturer of the bl...Continue Reading

References

Aug 1, 1995·The Journal of Pediatrics·A K ZaidiL B Reller
Jan 11, 1995·JAMA : the Journal of the American Medical Association·M S Rangel-FraustoR P Wenzel
Nov 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J SpitalnicL A Mermel
Apr 1, 1997·The Pediatric Infectious Disease Journal·J A KelloggD A Bankert
Dec 16, 1998·The Pediatric Infectious Disease Journal·A KarwowskaT Jadavji
Dec 1, 1999·Diagnostic Microbiology and Infectious Disease·N CornishJ A Washington
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S LiG R Corey
May 24, 2000·Journal of Clinical Pathology·P A James, K M al-Shafi
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C J GraceB Littenberg
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J.M.T. Hamilton-Miller
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cheol-In KangKang-Won Choe
Sep 25, 2003·Archives of Internal Medicine·Vance G FowlerEugene Z Oddone
Jun 25, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M S TabrizR Khatib
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F R CockerillW R Wilson
Oct 8, 2004·Revista española de cardiología·Dieter HorstkotteUNKNOWN Grupo de Trabajo de Endocarditis Infecciosa de la Sociedad Europea de Cardiología
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelRichard J Whitley
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L LemmingB Bruun
Feb 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN Infectious Diseases Society of America
Mar 16, 2005·Annals of Internal Medicine·Nasia SafdarDennis G Maki
Mar 10, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J W SmithM Shabaz Hasan
Jul 11, 2006·Rheumatology·G CoakleyUNKNOWN British Society for Rheumatology Standards, Guidelines and Audit Working Group
Oct 17, 2006·Clinical Microbiology Reviews·Keri K Hall, Jason A Lyman
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN American Thoracic Society
Feb 27, 2007·Intensive Care Medicine·Christoph EngelKonrad Reinhart
Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Britta LassmannJon E Rosenblatt
Jun 15, 2007·Journal of Clinical Microbiology·Emilio BouzaPatricia Muñoz
Jul 13, 2007·Journal of Clinical Microbiology·Lynn L HorvathDuane R Hospenthal
May 22, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Stefan Riedel, Karen C Carroll

❮ Previous
Next ❯

Citations

Dec 28, 2012·Journal of Clinical Microbiology·Jakko van IngenRon Bosboom
Oct 23, 2013·Critical Care : the Official Journal of the Critical Care Forum·Roland P H SchmitzFrank M Brunkhorst
Jul 2, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P PaveseP François
May 18, 2013·Diagnostic Microbiology and Infectious Disease·Caroline RönnbergVolkan Özenci
Apr 22, 2016·Jundishapur Journal of Microbiology·Mustafa AltindisOguz Karabay
Apr 22, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L Coorevits, A-M Van den Abeele
Oct 28, 2016·Journal of Medical Internet Research·Guna LeeJae-Ho Lee
Mar 18, 2016·PloS One·Franz RatzingerHeinz Burgmann
Nov 7, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Petra RoginaMiha Skvarc
Sep 29, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Annie I ChenIrving Nachamkin
Sep 27, 2019·Archives of Pathology & Laboratory Medicine·Lisa M StempakJohn E Leasure
Mar 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin C Hazen, Christopher R Polage
Dec 1, 2017·Critical Reviews in Microbiology·Walter FlorioAntonella Lupetti
Jun 9, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L CattoirA M Van den Abeele
Jul 2, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B Van den PoelJ Verhaegen
Dec 12, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Moonsuk BaeYong Pil Chong
Jul 28, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Francesca De PlatoPierluigi Viale
May 20, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·M Angeles OrellanaRafael Delgado
Jul 6, 2019·Frontiers in Medicine·Sien OmbeletLiselotte Hardy
Nov 25, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Brigitte LamyUNKNOWN ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis (ESGBIES)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.