PMID: 1540Nov 4, 1975

The prebiotic synthesis of deoxthymidine oligonucleotides. II. Comparison of condensing agents

Journal of Molecular Evolution
D G Odom, J T Brady

Abstract

A reaction which oligomerizes nucleotides under possible prebiotic conditions has been characterized. Nucleoside monophosphate in the presence of cyanamide at acid pH condenses to form dithymideine pyrophosphate and phosphodiester bonded compounds. Imidazole compounds and activated precursors such as nucleoside triphosphate are not necessary for this ologomerization reaction which produces primarily cyclic ologonucleotides.

References

Aug 7, 1969·Biochemical and Biophysical Research Communications·O Pongs, P O Ts'o
Oct 6, 1971·Journal of the American Chemical Society·O Pongs, P O Ts'o
Jan 1, 1974·Journal of Molecular Evolution·M S Verlander, L E Orgel
Nov 27, 1973·Journal of Molecular Evolution·M S VerlanderL E Orgel
Jan 1, 1974·Journal of Molecular Evolution·E Stephen-SherwoodJ Oro
Jan 1, 1972·Journal of Molecular Evolution·R Osterberg, L E Orgel
Jan 1, 1973·Journal of Molecular Evolution·R OsterbergR Lohrmann
May 7, 1971·Nature·C M Tapiero, J Nagyvary
Jan 1, 1971·Journal of Molecular Evolution·J D IbanezJ Oro
Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J SulstonH T Miles
Jun 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J SulstonH T Miles
Feb 14, 1970·Journal of Molecular Biology·R A Sanchez, L E Orgel
Jun 29, 1963·Annals of the New York Academy of Sciences·J Oro
Jul 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·G STEINMANM CALVIN

Citations

Mar 29, 1976·Journal of Molecular Evolution·D G OdomJ Oro
Jan 10, 2020·Chemical Reviews·Mahipal YadavRamanarayanan Krishnamurthy

Related Concepts

Origin of Life
Alkaline Phosphatase
Amines
Isocyanides
Biological Evolution
Hydrogen-Ion Concentration
Imidazoles
Oligodeoxyribonucleotides
Oligonucleotides
Phosphoric diester hydrolase

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.