PMID: 1540Nov 4, 1975

The prebiotic synthesis of deoxthymidine oligonucleotides. II. Comparison of condensing agents

Journal of Molecular Evolution
D G Odom, J T Brady


A reaction which oligomerizes nucleotides under possible prebiotic conditions has been characterized. Nucleoside monophosphate in the presence of cyanamide at acid pH condenses to form dithymideine pyrophosphate and phosphodiester bonded compounds. Imidazole compounds and activated precursors such as nucleoside triphosphate are not necessary for this ologomerization reaction which produces primarily cyclic ologonucleotides.


Aug 7, 1969·Biochemical and Biophysical Research Communications·O Pongs, P O Ts'o
Oct 6, 1971·Journal of the American Chemical Society·O Pongs, P O Ts'o
Jan 1, 1974·Journal of Molecular Evolution·M S Verlander, L E Orgel
Nov 27, 1973·Journal of Molecular Evolution·M S VerlanderL E Orgel
Jan 1, 1974·Journal of Molecular Evolution·E Stephen-SherwoodJ Oro
Jan 1, 1972·Journal of Molecular Evolution·R Osterberg, L E Orgel
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May 7, 1971·Nature·C M Tapiero, J Nagyvary
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Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J SulstonH T Miles
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Mar 29, 1976·Journal of Molecular Evolution·D G OdomJ Oro
Jan 10, 2020·Chemical Reviews·Mahipal YadavRamanarayanan Krishnamurthy

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