PMID: 9533949May 12, 1998Paper

The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants

Mechanisms of Development
J A BeloE M De Robertis

Abstract

Gsc-1 expression marks cells with Spemann organizer, or axis-inducing, activity in the vertebrate gastrula. Gsc-1 knockouts, however, did not display phenotypes related to the early phase of expression. In this paper, additional phenotypes for the Gsc-1 mouse mutant are presented. Examination of the base of the cranium in the dorsal view revealed fusions and deletions in the midline of the prechordal chondrocranium. These defects were correlated with the sites of expression of Gsc-1 in the prechordal plate/foregut endoderm in the day 7.5/8.5 embryo. Gsc-1 expression in proximal limb buds was correlated with malformations of the shoulder and hip articulations. In addition, ribs in the seventh cervical vertebra were observed with low penetrance. The role of Gsc-1 during gastrulation and axial development is discussed in relation to possible compensatory interactions with other genes such as HNF-3beta and the recently identified Gsc-2 and Gsc-3 genes.

References

Jul 12, 1991·Science·B BlumbergK W Cho
Nov 1, 1995·Genes & Development·I MatsuoS Aizawa
Mar 30, 1995·Nature·E M De Robertis
Mar 30, 1995·Nature·W Shawlot, R R Behringer
Nov 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K SulikG C Schoenwolf
Aug 1, 1994·Trends in Genetics : TIG·B G Herrmann, A Kispert
Jun 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S KurataniS Aizawa
Jul 1, 1997·Mechanisms of Development·M ArtingerK W Cho
Dec 1, 1996·Trends in Genetics : TIG·P Lemaire, L Kodjabachian
Nov 5, 1997·Mechanisms of Development·L Lemaire, M Kessel

❮ Previous
Next ❯

Citations

Apr 22, 2011·Development Genes and Evolution·Ana Cristina SilvaJosé António Belo
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiang FuWei Hsu
Sep 13, 2014·Science·Antonella LauriDetlev Arendt
Dec 10, 1999·Developmental Biology·L ZhuC D Stern
Jun 9, 2001·Developmental Biology·T A RodriguezR S Beddington
Nov 28, 2006·Mechanisms of Development·Samara L LewisPatrick P L Tam
May 20, 2008·Mechanisms of Development·Vanessa FranklinPatrick P L Tam
Mar 28, 2006·Developmental Biology·Olov AnderssonCarlos F Ibáñez
Aug 6, 2008·Developmental Biology·B McBratney-OwenG M Morriss-Kay
May 28, 2013·Current Opinion in Genetics & Development·Svetlana Gavrilov, Elizabeth Lacy
Jul 24, 2004·Seminars in Cell & Developmental Biology·Lorraine Robb, Patrick P L Tam
Jun 24, 2004·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Daniel E LiebermanBrandeis McBratney-Owen
Jan 13, 2018·Congenital Anomalies·Nandar MyaSachiko Iseki
May 26, 2007·The EMBO Journal·Veronika SanderE M De Robertis
Mar 12, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Brandeis M McBratneyScott Lozanoff
May 17, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Richard E PetersonMichael J Kern
Aug 24, 2018·Journal of Developmental Biology·Diana M Juriloff, Muriel J Harris
Jan 11, 2000·Journal of Cellular Biochemistry·P Kraus, T Lufkin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.