The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats

Brain Research
E A RybnikovaM O Samoilov

Abstract

The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hypoxia). As revealed by TUNEL assay, severe hypobaric hypoxia produced extensive apoptotic damage to the neurons of hippocampal CA1-CA4 and the neocortex but not the dentate gyrus granule cells. Remarkable posthypoxic up-regulation of Bax expression maximal at 24 h was detected in the CA1-CA4 areas of hippocampus and neocortex 3-72 h after severe hypoxia. The preconditioning to severe hypoxia protected neurons from the posthypoxic apoptotic transformations, the up-regulation of Bax expression, and resulted in persistent overexpression of Bcl-2 and Bcl-xL. We conclude that the protective action of hypoxic preconditioning is at least in part mediated by shifting of neuronal Bax/Bcl-2-Bcl-xL ratio to a favor of antiapoptotic proteins Bcl-2 and Bcl-xL.

References

Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KirinoA Tamura
Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1997·Annual Review of Neuroscience·D E Merry, S J Korsmeyer
Aug 1, 1998·Brain Research. Molecular Brain Research·C Bossenmeyer-Pourié, J L Daval
Mar 23, 2000·Cardiovascular Research·M NakamuraJ Vinten-Johansen
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ChenJ M Hallenbeck
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S ShimizuR P Simon
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
May 17, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Bernd Mayer, Rainer Oberbauer
Mar 20, 2004·Journal of Neurochemistry·Nicole M Jones, Marcelle Bergeron
Sep 8, 2005·Seminars in Cell & Developmental Biology·C GrimmM Gassmann

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Citations

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·D G SemenovM O Samoilov
Dec 18, 2008·Neuroscience and Behavioral Physiology·S A StroevM Pelto-Huikko
Oct 16, 2012·Sleep & Breathing = Schlaf & Atmung·Karin F HothMark S Aloia
Oct 19, 2010·Journal of Molecular Neuroscience : MN·Shiv S PrasadMargeryta Nowakowska
Mar 21, 2013·Neuroscience Research·Paul FuYuchuan Ding
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kalpana B HotaShashi B Singh
Sep 1, 2015·Neurochemical Research·Dmitry G SemenovJerzy W Lazarewicz
Mar 1, 2012·Neuroscience Letters·Elena RybnikovaMikhail Samoilov
Nov 19, 2013·Neuroscience Letters·Rudolf BrödemannAxel Becker
Jun 2, 2016·Neurobiology of Learning and Memory·Suryanarayan BiswalBhuvnesh Kumar
Jan 1, 2019·Experimental Physiology·Justin D SprickCaroline A Rickards
Jan 16, 2008·Physiological Reviews·Tihomir Paul Obrenovitch
Nov 12, 2015·Frontiers in Neuroscience·Elena Rybnikova, Mikhail Samoilov
Apr 22, 2017·Bulletin of Experimental Biology and Medicine·M O SamoilovE A Rybnikova
Aug 31, 2016·Journal of Neuroscience Research·Fengwu LiYuchuan Ding

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