The Precuneus - A Witness for Excessive Aβ Gathering in Alzheimer's Disease Pathology

Neuro-degenerative Diseases
Gayane AghakhanyanDuccio Volterrani

Abstract

Evidence of cortical beta-amyloid (Aβ) load, assessed by Aβ positron emission tomography (Aβ-PET), is an established in vivo biomarker of Alzheimer's disease (AD)-related pathophysiology. Qualitative assessment of Aβ-PET provides binary information; meanwhile semiquantitative approaches require a parcellation of PET image either manually or by placement of atlas-based volumes of interest. We supposed that a whole-brain approach with voxel-by-voxel standardized uptake value ratio (SUVr) parametric images may better elucidate the spatial trajectories of Aβ burden along the continuum of AD. We recruited 32 subjects with a diagnosis of probable AD dementia (ADD, n = 20) and mild cognitive impairment due to AD (MCI-AD, n = 12) according to the NIA-AA 2011 criteria. We also enrolled a control group of 6 cognitively healthy individuals (HCs) with preserved cognitive functions and negative Aβ-PET scan. The PET images were spatially normalized using the AV45 PET template in the MNI brain space. Subsequently, parametric SUVr images were calculated using the whole cerebellum as a reference region. A voxel-wise analysis of covariance was used to compare (between groups) the Αβ distribution pattern considering age as a nuisance covariate. B...Continue Reading

References

Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Apr 3, 2009·Brain : a Journal of Neurology·Clifford R JackUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Alberto Serrano-PozoBradley T Hyman
Nov 28, 2012·Nature Reviews. Neurology·Reisa A SperlingKeith A Johnson
Jan 31, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Keith A JohnsonUNKNOWN Amyloid Imaging Taskforce
Mar 1, 2013·Neurology·Clifford R JackRonald C Petersen
Mar 16, 2013·Nature Reviews. Drug Discovery·Paul S AisenHarald Hampel
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark E SchmidtUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 15, 2015·AJNR. American Journal of Neuroradiology·A P NayateUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 5, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Abhinay D JoshiMichael D Devous
Feb 4, 2016·Alzheimer Disease and Associated Disorders·Eek-Sung LeeUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 31, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Niklas MattssonEnchi Liu
Mar 21, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron P SchultzReisa A Sperling
Oct 27, 2017·European Journal of Epidemiology·Alison K OwerUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 6, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David T JonesClifford R Jack

❮ Previous
Next ❯

Citations

Aug 9, 2021·Psychiatry Research. Neuroimaging·Bárbara Duarte-AbrittaSalvador M Guinjoan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.