The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities

Viruses
Elif Damla ArisanPinar Uysal-Onganer

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the betacoronavirus family, which causes COVID-19 disease. SARS-CoV-2 pathogenicity in humans leads to increased mortality rates due to alterations of significant pathways, including some resulting in exacerbated inflammatory responses linked to the "cytokine storm" and extensive lung pathology, as well as being linked to a number of comorbidities. Our current study compared five SARS-CoV-2 sequences from different geographical regions to those from SARS, MERS and two cold viruses, OC43 and 229E, to identify the presence of miR-like sequences. We identified seven key miRs, which highlight considerable differences between the SARS-CoV-2 sequences, compared with the other viruses. The level of conservation between the five SARS-CoV-2 sequences was identical but poor compared with the other sequences, with SARS showing the highest degree of conservation. This decrease in similarity could result in reduced levels of transcriptional control, as well as a change in the physiological effect of the virus and associated host-pathogen responses. MERS and the milder symptom viruses showed greater differences and even significant sequence gaps. This divergence away...Continue Reading

References

Feb 1, 1992·The Journal of Nutrition·C E WestA J van der Zijpp
Oct 1, 1994·Digestive Diseases and Sciences·E D EhrenpreisR M Craig
Jul 17, 1998·Advances in Experimental Medicine and Biology·M E Coussons-ReadM I Gilmour
Aug 26, 2003·The American Journal of Pathology·Yuan LiWen-Zhe Ho
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Nov 16, 2004·Journal of Virology·Shihua Lu, Bryan R Cullen
Dec 2, 2004·The European Respiratory Journal·K W TsangP L Ho
Feb 16, 2005·Expert Opinion on Investigational Drugs·K F Chung
Mar 17, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Ronald Y ChuangRoy H Doi
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Aug 5, 2006·The Journal of Biological Chemistry·Yamina BennasserKuan-Teh Jeang
Oct 19, 2007·Nature·Irene M PedersenMichael David
Dec 21, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Miguel A Alejandre-AlcázarRory E Morty
Mar 4, 2008·Biochimica Et Biophysica Acta·Kelly J Gordon, Gerard C Blobe
Apr 17, 2009·Journal of Virology·Zetang WuDeborah S Parris
Oct 27, 2009·Nucleic Acids Research·Lewis Y GeerStephen H Bryant
Nov 26, 2009·Proceedings of the American Thoracic Society·Rory E MortyOliver Eickelberg
Feb 1, 2011·Virology·Adam Grundhoff, Christopher S Sullivan
May 7, 2011·Bioinformatics·Arthur LiberzonJill P Mesirov
Jul 26, 2011·Biochemical and Biophysical Research Communications·Anita DreherBodil Norrild
Jun 30, 2012·Bioinformatics·Liguo WangWei Li
Jul 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Viraj R Sanghvi, Laura F Steel
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Rickard NordénSigvard Olofsson
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Feb 15, 2013·Journal of Hematology & Oncology·Kwan-Yeung WongChor-Sang Chim
Feb 19, 2013·Nature Immunology·Bryan R Cullen
Mar 29, 2013·The New England Journal of Medicine·Harry L A JanssenMichael R Hodges
May 4, 2013·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Debra J Reid, Nga T Pham
Jun 7, 2013·Cellular and Molecular Life Sciences : CMLS·Jennifer S GrantAndrew H Baker
Jun 28, 2013·Frontiers in Genetics·Fabiola OlivieriFrancesca Fazioli
Oct 31, 2013·Methods in Molecular Biology·Fabian Sievers, Desmond G Higgins
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mazhar Hussain, Sassan Asgari

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Citations

Aug 21, 2020·Expert Review of Anti-infective Therapy·Neeraj ChauhanMurali M Yallapu
Aug 23, 2020·HLA : Immune Response Genetics·Antonio NovelliFranco Locatelli
Oct 20, 2020·Frontiers in Microbiology·Pallabi Bhattacharyya, Subhas C Biswas
Nov 26, 2020·Pathogens and Disease·Thekra KhushafaZhu Haixia
Jan 6, 2021·Journal of Oral Biology and Craniofacial Research·Alieh FarshbafSeyed Abdolrahim Rezaee
Nov 2, 2020·Journal of Translational Medicine·S GrecoF Martelli
Dec 22, 2020·World Journal of Clinical Cases·Hong-Ming ZhuMei Zhang
Dec 5, 2020·Viruses·Hanna HenzingerMartin Pichler
Mar 3, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ariana CentaLuciane R Cavalli
Mar 31, 2021·Journal of Pharmaceutical Analysis·Leonny Dwi Rizkita, Indwiani Astuti
Mar 31, 2021·Scandinavian Journal of Immunology·Juan Bautista De SanctisMarián Hajduch
Apr 4, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rafael MarchiLuciane R Cavalli
Dec 1, 2020·Non-coding RNA Research·Saeideh Jafarinejad-FarsangiMorteza Hadizadeh
Apr 22, 2021·Metabolic Brain Disease·Gurjit Kaur BhattiJasvinder Singh Bhatti
Jul 3, 2021·International Journal of Molecular Sciences·María Asunción Barreda-MansoRodrigo M Maza
Jul 20, 2021·Archives of Virology·Jiulue HuHamed Serati-Nouri
Jul 28, 2021·Physical Activity and Nutrition·Bok Sil Hong, Myoung-Ryu Kim
Aug 13, 2021·Environmental Science and Pollution Research International·Sherihan G AbdelHamidNadia M Hamdy
Aug 29, 2021·Pharmaceuticals·Swayam Prakash SrivastavaJulie E Goodwin
Aug 24, 2021·Immunobiology·Juliana M SerpeloniLuciane R Cavalli
Jun 29, 2021·Cell Biology International·Hao YingMaryam Farzaneh
Oct 31, 2021·BMC Research Notes·Seyyed Reza MousaviHajie Lotfi
Dec 16, 2021·Nucleic Acids Research·Joshua A ImperatoreMihaela Rita Mihailescu

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Datasets Mentioned

BETA
OC43
LC528232.1
MT198652.2
PRJNA615032

Methods Mentioned

BETA
biopsy
biopsies
MDS
glycosylation
sedation

Software Mentioned

BLAST
topGO R
DEseq2
DESeq2 R library
RSeQC
OnRamp
miRTarget
HTseq
Elim
DianaTools

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