The predictive capacity of apparent diffusion coefficient (ADC) in response assessment of brain metastases following radiation

Clinical & Experimental Metastasis
Raphael JakubovicArjun Sahgal

Abstract

To investigate the predictive capacity of the apparent diffusion coefficient (ADC) as a biomarker of radiation response in brain metastases. Seventy brain metastases from 42 patients treated with either stereotactic radiosurgery or whole brain radiotherapy were imaged at baseline, 1 week, and 1 month post-treatment using diffusion-weighted MRI. Mean and median relative ADC for metastases was calculated by normalizing ADC measurements to baseline ADC. At 1 year post-treatment, or last available follow-up MRI, volume criteria determined final tumour response status. Uni- and multivariate analysis was used to account for factors associated with tumour response at 1 week and 1 month. A generalized estimating equations model took into consideration multiple tumours per subject. Optimal thresholds that distinguished responders from non-responders, as well as sensitivity and specificity were determined by receiver operator characteristic analysis and Youden's index. Lower relative ADC values distinguished responders from non-responders at 1 week and 1 month (P < 0.05). Optimal cut-off values for response were 1.060 at 1 week with a sensitivity and specificity of 75.0 and 56.3 %, respectively. At 1 month, the cut-off was 0.971 with a s...Continue Reading

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Citations

Mar 18, 2017·Physics in Medicine and Biology·Faisal MahmoodRasmus H Hansen
Mar 13, 2019·Journal of Magnetic Resonance Imaging : JMRI·Frank RiemerFerdia A Gallagher
Feb 23, 2020·Nature Reviews. Clinical Oncology·John H SuhEric L Chang
Mar 29, 2020·AJNR. American Journal of Neuroradiology·C DodsonN H Ramaiya
Mar 20, 2021·Journal of Neuro-oncology·Casey Y LeeCharles H Cunningham

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