The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer.

Cancer Biomarkers : Section a of Disease Markers
Willi PieperNorbert Nass

Abstract

Neuronatin (NNAT) determined by immunohistochemistry is a negative prognostic biomarker for breast cancer, independent of the major clinicopathological markers. Here, we investigated whether NNAT is also a predictive biomarker for pathological remission after neoadjuvant chemotherapy. One hundred and four breast cancer patients, treated with systemic neoadjuvant chemotherapy were included in this retrospective study. NNAT was detected in formaldehyde fixed, paraffin embedded primary cancer tissue by immunohistochemistry and an immuno-reactive score (IRS) determined. Pathological remission was scored according to Sinn and by evaluation of cytopathic effects. NNAT-IRS was correlated with clinicopathological parameters as well as relapse free and overall survival and for pathological remission after neoadjuvant therapy. NNAT IRS was an independent prognostic marker for relapse free and overall survival and the time from diagnosis to the "tumor-free" state. NNAT IRS was associated with Luminal-A tumors and correlated slightly negative with age and lymph-node metastasis. There was no significant correlation of NNAT-IRS with Sinn's remission score, but with cytopathic effects of chemotherapy. We confirmed the prognostic impact of NNA...Continue Reading

References

Oct 1, 1994·Geburtshilfe und Frauenheilkunde·H P SinnH F Otto
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manfred KaufmannHans-Jörg Senn
Sep 7, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Teruhito UchiharaMasayuki Noguchi
Aug 15, 2008·Neuro-oncology·I-Mei SiuGregory J Riggins
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Aug 2, 2011·Lancet·Stephen K Chia, Antonio C Wolff
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Dec 19, 2013·Genome Biology·Marcus RennerGunhild Mechtersheimer
Aug 9, 2015·The Breast : Official Journal of the European Society of Mastology·Aleix PratMontserrat Muñoz
Feb 20, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sofia MaximianoManuel Morgado
May 5, 2016·Nucleic Acids Research·Maxim V KuleshovAvi Ma'ayan
May 26, 2017·Virchows Archiv : an International Journal of Pathology·Norbert NassThomas Kalinski
Oct 4, 2017·Southern Medical Journal·Susmitha Apuri
Jun 5, 2018·The New England Journal of Medicine·Prudence A FrancisUNKNOWN SOFT and TEXT Investigators and the International Breast Cancer Study Group
Jun 6, 2019·Breast Cancer Research and Treatment·Cody PlastererMichael J Flister

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Virchows Archiv : an International Journal of Pathology
Norbert NassThomas Kalinski
Journal of Cellular Physiology
Priyamvada M PitaleMarina Gorbatyuk
Journal of Diabetes Investigation
Shun-Ichiro Asahara
© 2021 Meta ULC. All rights reserved